Evidence map›Paper›PMID 34780699›Full record

ReviewACS chemical biology2021

Brightening up Biology: Advances in Luciferase Systems for

Shirley Liu, Yichi Su, Michael Z Lin, John A Ronald

Open access · greenAbstract readReview
In one paragraph

Review in ACS chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 112 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Shirley LiuRobarts Research Institute, The University of Western Ontario, London, Ontario N6A3K7, Canada.ORCID 0000-0003-4777-6917
Yichi SuDepartment of Neurobiology, Stanford University, Stanford, California 94305, United States.ORCID 0000-0001-5715-835X
Michael Z LinDepartment of Neurobiology, Stanford University, Stanford, California 94305, United States.ORCID 0000-0002-0492-1961
John A RonaldRobarts Research Institute, The University of Western Ontario, London, Ontario N6A3K7, Canada.
Stanford University · USWestern University · CA

Funding

Bioluminescent indicators for noninvasive imaging of acetylcholine releaseR21NS122055 · NINDS · STANFORD UNIVERSITY · PI LIN, MICHAEL Z. · 2021 to 2021
$434k
NINDS NIH HHS R21 NS122055
6 · The paper itself

Abstract

Bioluminescence imaging (BLI) using luciferase reporters is an indispensable method for the noninvasive visualization of cell populations and biochemical events in living animals. BLI is widely performed with preclinical rodent models to understand disease processes and evaluate potential cell- or gene-based therapies. However,

Indexed as

AnimalsDiagnostic ImagingGenetic TherapyHumansLimit of DetectionLuciferasesLuminescent AgentsLuminescent MeasurementsModels, AnimalOptical ImagingSensitivity and SpecificityLuciferasesLuminescent Agents

Identifiers

PMID34780699
PMCPMC8689642
OpenAlexW3212278529

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.