Evidence map›Paper›PMID 34780697›Full record

ArticleBiochemistry2021

Human Mat2A Uses an Ordered Kinetic Mechanism and Is Stabilized but Not Regulated by Mat2B.

Jonathan Bailey, Holly Douglas, Laura Masino, Luiz Pedro Sorio de Carvalho, Argyrides Argyrou

Open access · hybridAbstract read
In one paragraph

Article in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A genome-scale drug discovery pipeline uncovers therapeutic targets and a unique p97 allosteric binding site inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The potential and challenges of targetingFrontiers in oncology · 2023
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jonathan BaileyMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.ORCID 0000-0003-4088-8094
Holly DouglasMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.
Laura MasinoStructural Biology Scientific Technology Platform, The Francis Crick Institute, London NW1 1AT, United Kingdom.
Luiz Pedro Sorio de CarvalhoMycobacterial Metabolism and Antibiotic Research Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom.ORCID 0000-0003-2875-4552
Argyrides ArgyrouDiscovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.ORCID 0000-0003-3141-9122
The Francis Crick Institute · GBAstraZeneca (United Kingdom) · GB

Funding

Medical Research Council FC001060Wellcome Trust
6 · The paper itself

Abstract

Methionine adenosyltransferase (MAT) catalyzes the adenosine 5'-triphosphate (ATP) and l-methionine (l-Met) dependent formation of

Indexed as

Adenosine TriphosphateEnzyme StabilityHumansKineticsMethionineMethionine AdenosyltransferaseRecombinant ProteinsS-AdenosylmethionineAdenosine TriphosphateMAT2A protein, humanMAT2B protein, humanMethionineMethionine AdenosyltransferaseRecombinant ProteinsS-Adenosylmethionine

Identifiers

PMID34780697
PMCPMC8638259
OpenAlexW3211734656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.