Evidence map›Paper›PMID 34780578›Full record

ArticleEuropean stroke journal2021

European Stroke Organisation (ESO) guidelines on blood pressure management in acute ischaemic stroke and intracerebral haemorrhage.

Else Charlotte Sandset, Craig S Anderson, Philip M Bath, Hanne Christensen, Urs Fischer, Dariusz Gąsecki, Avtar Lal, Lisa S Manning, Simona Sacco, Thorsten Steiner and 1 more

Retracted Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European stroke journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. It is linked to trial NCT07527013 (Stratified Blood Pressure Management After Endovascular Treatment for Acute Ischemic Stroke), which is not on this map. Cited by 74 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 9 pooled it
22.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07527013 phase3not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Stratified Blood Pressure Management After Endovascular Treatment for Acute Ischemic Stroke (RESCUE-BP)

TypeinterventionalSponsorBeijing Tiantan HospitalRan2026 to 2028Enrolled544ConditionsEndovascular Therapy, Acute Ischaemic Stroke, Collateral Circulation, Blood Pressure ManagementArmsStratified Blood Pressure Management
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 9 syntheses or guidelines pooled it, 197 citations in OpenAlex.

  1. Pooled it
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 11 institutions in 11 countries.

Else Charlotte SandsetStroke Unit, Department of Neurology, Oslo University Hospital, Oslo, Norway.ORCID https://orcid.org/0000-0003-4312-4778
Craig S AndersonThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0002-7248-4863
Philip M BathStroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham NG7 2UH, United Kingdom.
Hanne ChristensenDepartment of Neurology, Bispebjerg Hospital & University of Copenhagen, Copenhagen, Denmark.
Urs FischerDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Dariusz GąseckiDepartment of Adult Neurology, Medical University of Gdańsk, Gdańsk, Poland.
Avtar LalMethodologist, European Stroke Organisation, Basel, Switzerland.
Lisa S ManningDepartment of Stroke Medicine, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
Simona SaccoDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.ORCID https://orcid.org/0000-0003-0651-1939
Thorsten SteinerDepartment of Neurology, Frankfurt Hoechst Hospital, Frankfurt, Germany.ORCID https://orcid.org/0000-0002-5080-8222
Georgios TsivgoulisSecond Department of Neurology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
European Stroke Organisation · CHGdańsk Medical University · PLGoethe University Frankfurt · DEOslo University Hospital · NOPeking University · CNUniversity Hospitals of Leicester NHS Trust · GBUniversity of Bern · CHUniversity of Copenhagen · DKUniversity of L'Aquila · ITUniversity of Nottingham · GBUniversity of Tennessee Health Science Center · US

Funding

Medical Research Council G0501797
6 · The paper itself

Abstract

The optimal blood pressure (BP) management in acute ischaemic stroke (AIS) and acute intracerebral haemorrhage (ICH) remains controversial. These European Stroke Organisation (ESO) guidelines provide evidence-based recommendations to assist physicians in their clinical decisions regarding BP management in acute stroke.The guidelines were developed according to the ESO standard operating procedure and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology. The working group identified relevant clinical questions, performed systematic reviews and meta-analyses of the literature, assessed the quality of the available evidence, and made specific recommendations. Expert consensus statements were provided where insufficient evidence was available to provide recommendations based on the GRADE approach. Despite several large randomised-controlled clinical trials, quality of evidence is generally low due to inconsistent results of the effect of blood pressure lowering in AIS. We recommend early and modest blood pressure control (avoiding blood pressure levels >180/105 mm Hg) in AIS patients undergoing reperfusion therapies. There is more high-quality randomised evidence for BP lowering in acute ICH, where intensive blood pressure lowering is recommended rapidly after hospital presentation with the intent to improve recovery by reducing haematoma expansion. These guidelines provide further recommendations on blood pressure thresholds and for specific patient subgroups. There is ongoing uncertainty regarding the most appropriate blood pressure management in AIS and ICH. Future randomised-controlled clinical trials are needed to inform decision making on thresholds, timing and strategy of blood pressure lowering in different acute stroke patient subgroups.

Indexed as

antihypertensiveblood pressureblood pressure loweringguidelineshypertensionintracerebral haemorrhageischaemic strokerecommendations

Identifiers

PMID34780578
PMCPMC8370078
OpenAlexW3162218120

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.