ArticlePloS one2021
Integrative analyses of metabolome and transcriptome reveals metabolomic variations and candidate genes involved in sweet cherry (Prunus avium L.) fruit quality during development and ripening.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 52 citations in OpenAlex.
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- IbMYB1-4 positively regulates purple stem and influences leaf color via dosage effect of gene expression in sweetpotato (Ipomoea batatas (L.) Lam.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Integrated metabolome and transcriptome reveal the molecular basis of flavonoid pathway-mediated fruit firmness variation in sweet cherry (Current research in food science · 2026Article
- Assessment of taste profile dynamics during crabapple (Frontiers in nutrition · 2026Article
- Metabolomic and transcriptomic analyses provide insights into metabolic networks during Fragaria nilgerrensis fruit development and ripening.BMC plant biology · 2025Article
- Widely Targeted Metabolomics Analysis Reveals Developmental Shifts in Antioxidants and Functional Peptides inAntioxidants (Basel, Switzerland) · 2025Article
- Identification of Candidate Gene Networks Controlling Soluble Sugar Metabolism DuringFoods (Basel, Switzerland) · 2025Article
- Proteo-metabolomic analysis of fruits reveals molecular insights into variations among Italian Sweet Cherry (Frontiers in plant science · 2025Article
- Insight into flavor difference of cherry (Food chemistry: X · 2024Article
- Bio-organic fertilizer affects secondary cell wall biosynthesis of Dendrocalamus farinosus by inhibiting the phenylpropanoid metabolic pathway.BMC plant biology · 2024Article
- Haplotype-resolved genome assembly for tetraploid Chinese cherry (Horticulture research · 2024Article
- Integrated metabolome and transcriptome analysis of differences in quality of ripe Lycium barbarum L. fruits harvested at different periods.BMC plant biology · 2024Article
- Editorial: Transcriptomics of fruit growth, development and ripening.Frontiers in plant science · 2024Article
- Transcriptomic and Metabolomic Profiling Reveals the Variations in Carbohydrate Metabolism between Two Blueberry Cultivars.International journal of molecular sciences · 2023Article
- Transcriptome Analysis Reveals Fruit Quality Formation inPlants (Basel, Switzerland) · 2023Article
- Tissue-Specific Transcriptome and Metabolome Analysis Reveals the Response Mechanism ofInternational journal of molecular sciences · 2023Article
- Integrative Analysis of the Transcriptome and Metabolome Reveals the Developmental Mechanisms and Metabolite Biosynthesis of the Tuberous Roots ofMolecules (Basel, Switzerland) · 2023Article
- Integrated Transcriptome and Metabolome Analyses Provide Insights into the Coloring Mechanism of Dark-red and Yellow Fruits in Chinese Cherry [International journal of molecular sciences · 2023Article
- Widely targeted metabolome profiling of different plateau raspberries and berry parts provides innovative insight into their antioxidant activities.Frontiers in plant science · 2023Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sweet cherry (Prunus avium L.), one of the most appreciated and most important commercial temperate fruits, has high sensory quality and nutritional value. Investigating its metabolic variations provides valuable information on the formation of fruit quality. In this study, widely targeted LC-MS/MS based metabolomics was used to identify and quantify metabolic changes during 'Black Pearl' sweet cherry development and ripening. A total of 263 significant differentially expressed metabolites (DEMs) were detected during the four fruit-development stages. Significant differences were observed in the composition and content of compounds in the four stages of cherry development, especially sugars, organic acids, and flavonoids. Moreover, transcriptome analysis provided a molecular basis for metabolic variations during fruit development. A total of 6724 significant differentially expressed genes (DEGs) were identified. Further correlation analysis of major DEMs and DEGs showed that 19 key DEGs were involved in sugar metabolism, 23 key DEGs in organic acid metabolism, and 13 key DEGs in flavonoid metabolism. The upregulated genes involved in the flavonoid pathway probably play an important role in regulating the rapid increase of anthocyanin content during fruit development. These comprehensive analysis data provide a better understanding to improve fruit quality traits based on molecular and metabolic levels.
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