Evidence map›Paper›PMID 34780280›Full record

ArticleInfection and immunity2022

CC16 Deficiency in the Context of Early-Life

Natalie Iannuzo, Michael Insel, Craig Marshall, William P Pederson, Kenneth J Addison, Francesca Polverino, Stefano Guerra, Julie G Ledford

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  5. [Protective effect ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
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  8. A comprehensive review ofFrontiers in medicine · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Natalie IannuzoDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, USA.
Michael InselDepartment of Medicine, University of Arizona, Tucson, Arizona, USA.
Craig MarshallDepartment of Medicine, University of Arizona, Tucson, Arizona, USA.
William P PedersonAsthma and Airway Disease Research Center, Tucson, Arizona, USA.
Kenneth J AddisonAsthma and Airway Disease Research Center, Tucson, Arizona, USA.
Francesca PolverinoDepartment of Medicine, University of Arizona, Tucson, Arizona, USA.
Stefano GuerraDepartment of Medicine, University of Arizona, Tucson, Arizona, USA.
Julie G LedfordDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0001-7977-4575
University of Arizona · USDermatology Research Center · US

Funding

PHYSIOLOGYT32HL007249 · NHLBI · UNIVERSITY OF ARIZONA · PI Brett A Colson, JOHN P KONHILAS · 1985 to 2026
$12.5M
CC16 in Childhood and Resilience to Persistent Asthma into Adult Life (Supplement)R01AI135108 · NIAID · UNIVERSITY OF ARIZONA · PI Stefano Guerra · 2017 to 2026
$5.4M
Defining mechanisms of CC16 on epithelial-driven host responses to pathogensR01HL142769 · NHLBI · UNIVERSITY OF ARIZONA · PI Julie Gunnells Ledford · 2019 to 2026
$4.2M
NHLBI NIH HHS R01 HL142769NHLBI NIH HHS T32 HL007249NIAID NIH HHS R01 AI135108
6 · The paper itself

Abstract

Studies have shown that club cell secretory protein (CC16) plays important protective roles in the lungs, yet its complete biological functions are unclear. We devised a translational mouse model in order to investigate the impact of early life infections, in the context of CC16 deficiency, on lung function in adult mice. CC16 sufficient (WT) and deficient (CC16

Indexed as

Pneumonia, MycoplasmaAnimalsDisease Models, AnimalEpithelial CellsLungMiceMycoplasma pneumoniaeairway remodelingCC16epithelial cellsinflammationlung infectionMycoplasma pneumoniae

Identifiers

PMID34780280
PMCPMC8853681
OpenAlexW3211376405

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.