Evidence map›Paper›PMID 34780257›Full record

ReviewAnnual review of physiology2022

Running the Female Power Grid Across Lifespan Through Brain Estrogen Signaling.

Holly A Ingraham, Candice B Herber, William C Krause

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. mSystems · 2024
    Article
  11. Review
  12. Introduction.Harvard review of psychiatry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Holly A IngrahamDepartment of Cellular and Molecular Pharmacology, School of Medicine, Mission Bay, University of California, San Francisco, California, USA; email: Holly.Ingraham@ucsf.edu.
Candice B HerberDepartment of Cellular and Molecular Pharmacology, School of Medicine, Mission Bay, University of California, San Francisco, California, USA; email: Holly.Ingraham@ucsf.edu.
William C KrauseDepartment of Cellular and Molecular Pharmacology, School of Medicine, Mission Bay, University of California, San Francisco, California, USA; email: Holly.Ingraham@ucsf.edu.
University of California, San Francisco · US

Funding

Dissecting a hormone-responsive processor for female activity and repetitive behaviorR01DK121657 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI INGRAHAM, HOLLY A. · 2020 to 2024
$2.9M
Mapping gut-spinal cord connections in visceral painU01NS113869 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI INGRAHAM, HOLLY A., JULIUS, DAVID · 2019 to 2021
$2.4M
Arcuate ERa Signaling in Central Control of Female Bone MetabolismR01AG062331 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI INGRAHAM, HOLLY A. · 2019 to 2023
$2.3M
Unraveling Mechanisms Driving Female-Specific Osteogenesis after Disrupting a Brain-to-Bone CircuitK01AG065916 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERBER, CANDICE · 2020 to 2021
$261k
Molecular Mechanisms of VMH-Specific Activation of Brown Adipose Tissue ThermogenesisF32DK107115 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERBER, CANDICE · 2016 to 2018
$117k
NIA NIH HHS K01 AG065916NIA NIH HHS R01 AG062331NIDDK NIH HHS F32 DK107115NIDDK NIH HHS R01 DK121657NINDS NIH HHS U01 NS113869
6 · The paper itself

Abstract

The role of central estrogen in cognitive, metabolic, and reproductive health has long fascinated the lay public and scientists alike. In the last two decades, insight into estrogen signaling in the brain and its impact on female physiology is beginning to catch up with the vast information already established for its actions on peripheral tissues. Using newer methods to manipulate estrogen signaling in hormone-sensitive brain regions, neuroscientists are now identifying the molecular pathways and neuronal subtypes required for controlling sex-dependent energy allocation. However, the immense cellular complexity of these hormone-sensitive brain regions makes it clear that more research is needed to fully appreciate how estrogen modulates neural circuits to regulate physiological and behavioral end points. Such insight is essential for understanding how natural or drug-induced hormone fluctuations across lifespan affect women's health.

Indexed as

EstrogensLongevityBrainFemaleHumansHypothalamusNeuronsSignal TransductionEstrogensarcuate nucleusbrain-bone connectioncentral estrogen signalingestrogen receptor alphafemale physiologyhypothalamusmenopausereproductionsex-dependent neurocircuitsventromedial hypothalamuswomen's health

Identifiers

PMID34780257
PMCPMC8831472
OpenAlexW3212198190

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.