Direct Measurement of Intermolecular Mechanical Force for Nonspecific Interactions between Small Molecules.

Shankar Pandey, Yuan Xiang, Dirk Friedrich, Yongsheng Leng, Hanbin Mao

Open access · greenAbstract read

In one paragraph

Article in The journal of physical chemistry letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 89% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shankar PandeyDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.ORCID https://orcid.org/0000-0001-5576-6714

Yuan XiangDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, D.C. 20052, United States.ORCID https://orcid.org/0000-0002-4665-3360

Dirk FriedrichDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.

Yongsheng LengDepartment of Mechanical and Aerospace Engineering, The George Washington University, Washington, D.C. 20052, United States.ORCID https://orcid.org/0000-0002-3558-5016

Hanbin MaoDepartment of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.ORCID https://orcid.org/0000-0002-6720-9429

Kent State University · USGeorge Washington University · US

Funding

Specific Recognition of G-quadruplexesR01CA236350 · NCI · KENT STATE UNIVERSITY · PI MAO, HANBIN · 2018 to 2022

$1.6M

NCI NIH HHS R01 CA236350

6 · The paper itself

Abstract

Mechanical force can evaluate intramolecular interactions in macromolecules. Because of the rapid motion of small molecules, it is extremely challenging to measure mechanical forces of nonspecific intermolecular interactions. Here, we used optical tweezers to directly examine the intermolecular mechanical force (IMMF) of nonspecific interactions between two cholesterols. We found that IMMFs of dimeric cholesterol complexes were dependent on the orientation of the interaction. The surprisingly high IMMF in cholesterol dimers (∼30 pN) is comparable to the mechanical stability of DNA secondary structures. Using Hess-like cycles, we quantified that changes in free energy of solubilizing cholesterol (Δ

Identifiers

PMID34780182

DOI10.1021/acs.jpclett.1c03142

PMCPMC8778946

OpenAlexW3212869285

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.