Evidence map›Paper›PMID 34780071›Full record

ArticleFEBS letters2021

Selenomethionine modulates insulin secretion in the MIN6-K8 mouse insulinoma cell line.

Lidan Zhao, Christopher M Carmean, Michael Landeche, Bijoy Chellan, Robert M Sargis

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Experimental Approaches to Diabetes Mellitus.The Eurasian journal of medicine · 2022
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lidan ZhaoDivision of Endocrinology, Diabetes, and Metabolism, College of Medicine, University of Illinois at Chicago, IL, USA.
Christopher M CarmeanDivision of Endocrinology, Diabetes, and Metabolism, College of Medicine, University of Illinois at Chicago, IL, USA.
Michael LandecheDivision of Endocrinology, Diabetes, and Metabolism, College of Medicine, University of Illinois at Chicago, IL, USA.
Bijoy ChellanDivision of Endocrinology, Diabetes, and Metabolism, College of Medicine, University of Illinois at Chicago, IL, USA.
Robert M SargisDivision of Endocrinology, Diabetes, and Metabolism, College of Medicine, University of Illinois at Chicago, IL, USA.ORCID 0000-0001-7061-2983
Illinois College · US

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Selenoproteins in Arsenic-Induced Metabolic DysfunctionR01ES028879 · NIEHS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SARGIS, ROBERT M · 2018 to 2022
$2.7M
Protection against Arsenic-Induced Neurologic Defects by Brain DHA EnrichmentR21ES030884 · NIEHS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SARGIS, ROBERT M · 2019 to 2020
$440k
NIEHS NIH HHS P30 ES027792NIEHS NIH HHS R01 ES028879NIEHS NIH HHS R21 ES030884
6 · The paper itself

Abstract

Selenium is an essential trace element of interest for its potential role in glucose homeostasis. The present study investigated the impact of selenium supplementation as selenomethionine (SeMet) on insulin secretion in MIN6-K8 cells, a pancreatic β-cell model. We found that SeMet enhanced percent glucose-induced insulin secretion, while also increasing tolbutamide- and KCl-induced percent insulin secretion. RNA-sequencing showed that SeMet supplementation altered expression of several selenoproteins, including glutathione peroxidase 3 (Gpx3) and selenoprotein P (SelP). Targeted knockdown of Gpx3 increased both percent and total insulin release, while SelP knockdown increased insulin content and insulin release. Collectively, these studies support a putative role for selenium and selenoproteins in the regulation of insulin secretion, glucose homeostasis, and diabetes risk.

Indexed as

AnimalsCalciumCell DeathCell Line, TumorCell SurvivalGene Expression Regulation, NeoplasticGlutathione PeroxidaseInsulinInsulinomaInsulin SecretionMicePotassiumRNA, MessengerSelenomethionineSelenoproteinsTolbutamideCalciumGlutathione PeroxidaseGpx3 protein, mouseInsulinPotassiumRNA, MessengerSelenomethionineSelenoproteinsTolbutamideglutathione peroxidase 3insulin secretionMIN6-K8 cellsSeleniumselenomethionineselenoprotein P

Identifiers

PMID34780071
PMCPMC10924436
OpenAlexW3213837339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.