SynthesisAnnals of the New York Academy of Sciences2022
Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta-analysis.
Synthesis in Annals of the New York Academy of Sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Calcium Supplementation in Pregnancy: A Systematic Review of Clinical Studies.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Harnessing behavioral interventions to enhance micronutrient intake in pregnancy: A comprehensive review.Journal of education and health promotion · 2025Review
- Global prevalence of diet low in calcium and the disease burden: results from the Global Burden of Disease Study 2019.Nutrition & diabetes · 2024Article
- Altering maternal calcium and phosphorus dietary intake induces persistent sex-specific changes in the dentition of the offspring.Orthodontics & craniofacial research · 2024Article
- Longitudinal changes of the femoral bone mineral density from first to third trimester of pregnancy: bone health assessment by means of non-ionizing REMS technology.Aging clinical and experimental research · 2024Article
- Supplement use in relation to dietary intake in pregnancy: an analysis of the Swedish GraviD cohort.The British journal of nutrition · 2024Article
- A comprehensive review on the impact of calcium and vitamin D insufficiency and allied metabolic disorders in females.Food science & nutrition · 2023Review
- Early Life Programming of Skeletal Health.Current osteoporosis reports · 2023Review
- Pregnancy- and lactation-induced osteoporosis: a social-media-based survey.BMC pregnancy and childbirth · 2023Article
- Calcium deficiency worldwide: prevalence of inadequate intakes and associated health outcomes.Annals of the New York Academy of Sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insufficient calcium intake during pregnancy may lead to maternal bone resorption and lower bone density of offspring. We evaluated the impact of supplementary calcium with or without vitamin D during pregnancy on maternal and offspring bone mineral density (BMD) and teeth firmness of the offspring. Randomized controlled trials (RCTs) were searched systematically in 11 databases. Two researchers independently screened the titles and abstracts of 3555 records and the full texts of 31 records to examine eligibility. The search yielded seven RCTs (11 reports, n = 1566). No advantage of calcium supplementation was found on maternal BMD after delivery or during breastfeeding, or on offspring BMD, even when dietary calcium intake was low. The results were neither modified by the dose of calcium nor concomitant vitamin D administration. A suspicion of some long-term harm of the intervention on maternal BMD and growth of female offspring was raised based on the data. One study suggested some benefit of high-dose calcium supplementation on offspring teeth firmness at 12 years old. A low number of the studies and abundant missing data reduced the quality of the findings. The impact of calcium supplementation on maternal and offspring bone health was deemed unknown because of inconclusive research results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.