ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2022
Impact of residual subtraction on myocardial blood flow and reserve estimates from rapid dynamic PET protocols.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Evaluation of Myocardial Blood Flow UsingCurrent cardiology reports · 2026Review
- The role of cardiac PET in diagnosis and prognosis of patients with ischemia with no obstructive coronary arteries (INOCA).American heart journal plus : cardiology research and practice · 2024Article
- Integrated myocardial flow reserve (iMFR) assessment: optimized PET blood flow quantification for diagnosis of coronary artery disease.European journal of nuclear medicine and molecular imaging · 2023Article
- Measuring myocardial blood flow using dynamic myocardial perfusion SPECT: artifacts and pitfalls.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Accounting for residual activity in the estimate of myocardial blood flow with PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background
methodsWe retrospectively analyzed 63 patients who underwent a dynamic ammonia rest/stress study and 231 patients from the flurpiridaz 301 trial. Residual subtraction was performed by subtracting the mean pre-injection activity in each sampled region from that region's time activity curve. Corrected and uncorrected MBF and MFR were analyzed. Diagnostic accuracy was compared to quantitative coronary angiograms (QCA) for the flurpiridaz population.
resultsWith delays between injections above 3 half-lives, and a doubled stress dose, residual activity did not meaningfully increase ammonia MBF (< 5%). For shorter injection delays, stress MBF was overestimated by 13.6% ± 5.0% (P < .001). Residual activity had a large effect on flurpiridaz stress MBF, overestimating it by 37.9% ± 23.2% (P < .001). Comparison to QCA showed a significant improvement in AUC with residual subtraction (from 0.748 to 0.831, P = .001). MFR yielded similar results.
conclusionsAccounting for residual activity has a marked impact on stress MBF and MFR and improves diagnostic accuracy relative to QCA.
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Registered trials
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