Evidence map›Paper›PMID 34779969›Full record

ReviewMolecular imaging and biology2023

Two-Photon Endoscopy: State of the Art and Perspectives.

Vytautas Kučikas, Maximilian P Werner, Thomas Schmitz-Rode, Frédéric Louradour, Marc A M J van Zandvoort

Open access · hybridAbstract readReview
In one paragraph

Review in Molecular imaging and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. In Vivo Microendoscopy in the Near-Infrared II Window.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. A novel histological occlusion classification for coiled aneurysms based on multiphoton microscopy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Vytautas KučikasInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany. vkucikas@ukaachen.de.
Maximilian P WernerDepartment of Biohybrid and Medical Textiles (BioTex), RWTH Aachen University, Aachen, Germany.
Thomas Schmitz-RodeDepartment of Biohybrid and Medical Textiles (BioTex), RWTH Aachen University, Aachen, Germany.
Frédéric LouradourXLIM Research Institute, Limoges University, CNRS, Limoges, France.
Marc A M J van ZandvoortInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.
RWTH Aachen University · DECentre National de la Recherche Scientifique · FRMaastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the demand for non-destructive deep-tissue imaging modalities has led to interest in multiphoton endoscopy. In contrast to bench top systems, multiphoton endoscopy enables subcellular resolution imaging in areas not reachable before. Several groups have recently presented their development towards the goal of producing user friendly plug and play system, which could be used in biological research and, potentially, clinical applications. We first present the technological challenges, prerequisites, and solutions in two-photon endoscopic systems. Secondly, we focus on the applications already found in literature. These applications mostly serve as a quality check of the built system, but do not answer a specific biomedical research question. Therefore, in the last part, we will describe our vision on the enormous potential applicability of adult two-photon endoscopic systems in biological and clinical research. We will thus bring forward the concept that two-photon endoscopy is a sine qua non in bringing this technique to the forefront in clinical applications.

Indexed as

Biomedical ResearchEndoscopyDiagnostic ImagingPhotonsColon imagingIn vivo imagingKidney imagingLabel freeMultiphoton endoscopyNonlinear endoscopy

Identifiers

PMID34779969
PMCPMC9971078
OpenAlexW3212631422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.