Evidence map›Paper›PMID 34779901›Full record

ArticleAnalytical and bioanalytical chemistry2022

A low-cost self-dispersing method of droplet array generation enabled by a simple reusable mask for bioanalysis and bioassays.

Kai Liu, Yang Pan, Xiaojie Wang, Tuo Ma, Baoqing Li, Jiaru Chu

Abstract read
PubMed Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Precise loading of scarce reagents on droplet microarrays.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kai Liu *Department of Precision Machinery & Precision Instrumentation, University of Science & Technology of China, Hefei, 230027, Anhui, China.
Yang Pan *Department of Precision Machinery & Precision Instrumentation, University of Science & Technology of China, Hefei, 230027, Anhui, China.
Xiaojie WangDepartment of Precision Machinery & Precision Instrumentation, University of Science & Technology of China, Hefei, 230027, Anhui, China.
Tuo MaDepartment of Precision Machinery & Precision Instrumentation, University of Science & Technology of China, Hefei, 230027, Anhui, China.
Baoqing LiDepartment of Precision Machinery & Precision Instrumentation, University of Science & Technology of China, Hefei, 230027, Anhui, China. bqli@ustc.edu.cn.
Jiaru ChuDepartment of Precision Machinery & Precision Instrumentation, University of Science & Technology of China, Hefei, 230027, Anhui, China.
University of Science and Technology of China · CN

Funding

Fundamental Research Funds for the Central Universities No. WK5290000001Joint Research Fund for Overseas Chinese Scholars and Scholars in Hong Kong and Macao No. 51929501National Natural Science Foundation of China No. 51675505Strategic Priority Research Program (C) of the CAS No. XDC07040200
6 · The paper itself

Abstract

Discontinuous dewetting is an attractive technique that can produce droplet array of specific volume, geometry and at predefined location on a substrate. Droplet array has great potential in bioanalysis such as high-throughput live cell screening, digital PCR, and drug candidates. Here, we propose a self-dispersing droplet array generation method, which has advantages of low cost, simple operation, and easy large-area production ability. Droplet array of specific volumes was generated on a polymethyl methacrylate (PMMA) substrate using a simple reusable polyimide (PI) adhesive mask. Experiment shows that the generated droplet array can be used to successfully capture single particles which obeys Poisson distribution in a high-throughput manner. Furthermore, a droplet-array sandwiching chip was created based on the self-dispersion method for rapid detection of human serum albumin (HSA) at wide range of 183-11,712 μg/mL with low reagent consumption of 2.2 μL, demonstrating its potential applications in convenient high-throughput bioanalysis and bioassays.

Indexed as

Biological AssayHigh-Throughput Screening AssaysMicrofluidic Analytical TechniquesBioanalysis and bioassaysDiscontinuous dewettingDroplet arrayReusable mask

Identifiers

PMID34779901
OpenAlexW3213450491

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.