Evidence map›Paper›PMID 34779873›Full record

ArticleEuropean radiology2022

Prognostic value of total metabolic tumour volume and therapy-response assessment by [

Alessio Annovazzi, Virginia Ferraresi, Sandra Rea, Michelangelo Russillo, Davide Renna, Silvia Carpano, Rosa Sciuto

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in European radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  7. Review on radiomic analysis inCancer imaging : the official publication of the International Cancer Imaging Society · 2024
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  9. Closing.The Journal of clinical and aesthetic dermatology · 2023
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  10. Melanin-targeted [European journal of nuclear medicine and molecular imaging · 2023
    Observational
  11. Article
  12. The Role and Potential ofDiagnostics (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Alessio AnnovazziNuclear Medicine Unit, IRCCS - Regina Elena National Cancer Institute, Via Elio Chianesi, 53, 00144, Rome, Italy. alessio.annovazzi@ifo.gov.it.ORCID http://orcid.org/0000-0002-4887-7982
Virginia FerraresiFirst Division of Medical Oncology, IRCCS - Regina Elena National Cancer Institute, Rome, Italy.
Sandra ReaNuclear Medicine Unit, IRCCS - Regina Elena National Cancer Institute, Via Elio Chianesi, 53, 00144, Rome, Italy.
Michelangelo RussilloFirst Division of Medical Oncology, IRCCS - Regina Elena National Cancer Institute, Rome, Italy.
Davide RennaFirst Division of Medical Oncology, IRCCS - Regina Elena National Cancer Institute, Rome, Italy.
Silvia CarpanoSecond Division of Medical Oncology, IRCCS - Regina Elena National Cancer Institute, Rome, Italy.
Rosa SciutoNuclear Medicine Unit, IRCCS - Regina Elena National Cancer Institute, Via Elio Chianesi, 53, 00144, Rome, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITNational Cancer Institute · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTarget therapy with BRAF/MEK inhibitors in metastatic melanoma is characterised by a high response rate; however, acquired resistance to treatment develops in many cases. We aimed to investigate if baseline total metabolic tumour volume (TMTV) and therapy-response assessment by [

methodsFifty-seven patients who performed an [

resultsAccording to EORTC criteria, 34 patients were classified as responders (partial/complete metabolic response [PMR/CMR]) and 23 as non-responders (progressive/stable metabolic disease [PMD/SMD]). Baseline characteristics associated with a shorter PFS were more than two metastatic organ sites and TMTV > 56 cm

conclusionsBaseline TMTV and metabolic response may be useful prognostic indicators for PFS and OS in patients with advanced melanoma treated with BRAF/MEK inhibitors. KEY POINTS: • In a retrospective cohort of 57 metastatic melanoma patients treated with BRAF/MEK inhibitors, a TMTV > 56 cm

Indexed as

MelanomaNeoplasms, Second PrimaryFluorodeoxyglucose F18HumansMitogen-Activated Protein Kinase KinasesPositron Emission Tomography Computed TomographyPrognosisProtein Kinase InhibitorsProto-Oncogene Proteins B-rafRetrospective StudiesTumor BurdenBRAF protein, humanFluorodeoxyglucose F18Mitogen-Activated Protein Kinase KinasesProtein Kinase InhibitorsProto-Oncogene Proteins B-rafMelanomaMitogen-activated protein kinasesPatient outcome assessmentPositron emission tomography computed tomographyProto-oncogene proteins B-raf

Identifiers

PMID34779873
OpenAlexW3211479645

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.