Evidence map›Paper›PMID 34779841›Full record

ReviewEmerging topics in life sciences2021

It takes guts to learn: machine learning techniques for disease detection from the gut microbiome.

Kristen D Curry, Michael G Nute, Todd J Treangen

Open access · bronzeAbstract readReview
In one paragraph

Review in Emerging topics in life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Decoding the rhizosphere microbiome againstFrontiers in microbiomes · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kristen D CurryDepartment of Computer Science, Rice University, Houston, TX 77005, USA.ORCID 0000-0001-8375-397X
Michael G NuteDepartment of Computer Science, Rice University, Houston, TX 77005, USA.ORCID 0000-0003-4129-6525
Todd J TreangenDepartment of Computer Science, Rice University, Houston, TX 77005, USA.ORCID 0000-0002-3760-564X
Rice University · US

Funding

TRAINING PROGRAM IN COMPUTATIONAL BIOLOGY AND MEDICINET15LM007093 · NLM · RICE UNIVERSITY · PI Lydia E. Kavraki · 1992 to 2026
$20.8M
Project 3: Functional Microbiome and Host Signatures in Transition from Commensal to pathogenP01AI152999 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO, SAVIDGE, TOR C. · 2020 to 2025
$12.0M
NIAID NIH HHS P01 AI152999NLM NIH HHS T15 LM007093
6 · The paper itself

Abstract

Associations between the human gut microbiome and expression of host illness have been noted in a variety of conditions ranging from gastrointestinal dysfunctions to neurological deficits. Machine learning (ML) methods have generated promising results for disease prediction from gut metagenomic information for diseases including liver cirrhosis and irritable bowel disease, but have lacked efficacy when predicting other illnesses. Here, we review current ML methods designed for disease classification from microbiome data. We highlight the computational challenges these methods have effectively overcome and discuss the biological components that have been overlooked to offer perspectives on future work in this area.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaHumansMachine LearningMetagenomeMetagenomicsbioinformaticshost–microbe interactionsmachine learningmicrobiome

Identifiers

PMID34779841
PMCPMC8786294
OpenAlexW3211527264

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.