Evidence map›Paper›PMID 34779770›Full record

ArticleeLife2021

Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C

Marcial Camacho, Bradley Quade, Thorsten Trimbuch, Junjie Xu, Levent Sari, Josep Rizo, Christian Rosenmund

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Munc13-1 couples DAG and CaScience advances · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Fusion Pores as Regulators of Quantal Size and Cellular Physiology.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  9. Article
  10. Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Taking a closer look at the synapse.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Different states of synaptic vesicle priming explain target cell type-dependent differences in neurotransmitter release.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. Article
  19. Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Marcial Camacho *Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Neurophysiology, Berlin, Germany.ORCID 0000-0002-2367-1259
Bradley Quade *Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-5330-1355
Thorsten TrimbuchCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Neurophysiology, Berlin, Germany.
Junjie XuDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.
Levent SariDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.
Josep RizoDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0003-1773-8311
Christian RosenmundCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Neurophysiology, Berlin, Germany.ORCID 0000-0002-3905-2444
The University of Texas Southwestern Medical Center · USHumboldt-Universität zu Berlin · DE

Funding

Mechanisms of neurotransmitter release and its regulationR35NS097333 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI RIZOREY, JOSE · 2017 to 2024
$7.0M
Molecular Biophysics Predoctoral Training ProgramT32GM008297 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI CHOOK, YUH MIN · 1989 to 2018
$2.4M
NIGMS NIH HHS T32 GM008297NINDS NIH HHS R35 NS097333
6 · The paper itself

Abstract

Munc13-1 plays a central role in neurotransmitter release through its conserved C-terminal region, which includes a diacyglycerol (DAG)-binding C

Indexed as

AnimalsBiological TransportBiophysical PhenomenaCell CommunicationCell MembraneCells, CulturedHippocampusIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutMolecular Dynamics SimulationMutationNerve Tissue ProteinsNeuronsNeurotransmitter AgentsSynaptic TransmissionIntracellular Signaling Peptides and ProteinsNerve Tissue ProteinsNeurotransmitter AgentsUnc13a protein, mouseUnc13b protein, mousemouseMunc13neuroscienceneurotransmitter releasepresynaptic plasticitysynaptic vesicle fusion

Identifiers

PMID34779770
PMCPMC8648301
OpenAlexW3213906025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.