ArticleeLife2021
ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer.
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Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
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Who cites it
30 citing papers in PubMed, 34 citations in OpenAlex.
- Beyond hypoxia and ccRCC: the expanding universe of VHL novel targets and next-generation therapeutics.Biomarker research · 2026Review
- ZHX2 Alleviates Vascular Remodeling and Smooth Muscle Cell Proliferation by Transcriptional Regulation of GADD45G.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- NUSAP1 Recruits DAXX to Suppress HIF-Driven Triple-Negative Breast Cancer Progression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Histone lysine demethylases in breast cancer: molecular mechanisms, biological functions, and therapeutic intervention.Molecular cancer · 2025Review
- KDM3A drives NSCLC proliferation and metastasis via H3K9 demethylation, EMT activation and MMP-9 upregulation.Biomolecules & biomedicine · 2025Article
- Liquid-liquid phase separation of ZHX2 protects DLBCL cells against ferroptosis through induction of SLC3A2.Leukemia · 2025Article
- Hypoxia-specific transcriptional condensates drive metastasis.Trends in cell biology · 2025Article
- ZHX2 inhibits diabetes-induced liver injury and ferroptosis by epigenetic silence of YTHDF2.Nutrition & diabetes · 2025Article
- Evaluation of the zinc-fingers and homeoboxes 3 as a potential biomarker for prognosis prediction in lung adenocarcinoma.Frontiers in medicine · 2025Article
- Comprehensive Analysis of the Prognostic Significance of ZHX Family Members in Esophageal Carcinoma.International journal of general medicine · 2025Article
- Von Hippel-Lindau protein signalling in clear cell renal cell carcinoma.Nature reviews. Urology · 2024Review
- VHL suppresses UBE3B-mediated breast tumor growth and metastasis.Cell death & disease · 2024Article
- Therapeutic Targeting of Hypoxia-Inducible Factors in Cancer.International journal of molecular sciences · 2024Review
- Relationship between ZHX2 Expression and VHL Gene Alteration in VHL-associated and Sporadic Hemangioblastomas of the Central Nervous System.Journal of kidney cancer and VHL · 2024Article
- Characterization of circSEC11A as a novel regulator of Iodine-125 radioactive seed-induced anticancer effects in hepatocellular carcinoma via targeting ZHX2/GADD34 axis.Cell death discovery · 2023Article
- ZHX2 deficiency enriches hybrid MET cells through regulating E-cadherin expression.Cell death & disease · 2023Article
- Zinc fingers and homeoboxes 2 inhibition could suppress the proliferation of ovarian cancer cells by apoptosis pathway.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023Article
- Decreased zinc-fingers and homeoboxes family expression was associated with unfavorable outcomes and immune infiltration in lung adenocarcinoma.Translational cancer research · 2023Article
- Article
- Hypoxia-induced YAP activation and focal adhesion turnover to promote cell migration in mesenchymal TNBC cells.Cancer medicine · 2023Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 5 countries.
Wentong Fang *Department of Pharmacy, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID 0000-0003-0047-1198
Chengheng Liao *Department of Pathology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-9073-3835
Rachel ShiDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, United States.
Jeremy M SimonLineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel hill, United States.ORCID 0000-0003-3906-1663
Travis S PtacekLineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel hill, United States.
Giada ZurloDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, United States.
Youqiong YeShanghai Institute of Immunology, Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Leng HanDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, United States.
Cheng FanLineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel hill, United States.
Lei BaoDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, United States.
Christopher Llynard OrtizInstitute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan.ORCID 0000-0002-3114-7369
Hong-Rui LinInstitute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan.
Ujjawal ManochaLineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel hill, United States.
Weibo LuoDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, United States.
Yan PengDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, United States.
William Y KimLineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel hill, United States.
Lee-Wei YangInstitute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu, Taiwan.ORCID 0000-0002-3971-6386
Qing ZhangDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, United States.ORCID 0000-0002-6595-8995
The University of Texas Southwestern Medical Center · USUNC Lineberger Comprehensive Cancer CenterNational Tsing Hua University · TWJiangsu Province Hospital · CNShanghai Jiao Tong University · CNThe University of Texas Health Science Center at Houston · US
Funding
UNC Neuroscience Center Research Cores: MicroscopyP30NS045892 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2003 to 2022
$11.5MExploration of ZHX2 as a novel substrate of pVHL and an oncogenic driver of renal cancerR01CA211732 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI ZHANG, QING · 2017 to 2021
$2.1MBBOX1 is a Novel Oncogenic Driver in Triple Negative Breast CancerR01CA256833 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI ZHANG, QING · 2021 to 2025
$2.0MNCI NIH HHS R01 CA211732NCI NIH HHS R01 CA256833NINDS NIH HHS P30 NS045892
Abstract
Triple-negative breast cancer (TNBC) is an aggressive and highly lethal disease, which warrants the critical need to identify new therapeutic targets. We show that Zinc Fingers and Homeoboxes 2 (
Indexed as
Gene Expression Regulation, NeoplasticCarcinogenesisCell Line, TumorGene Expression ProfilingHomeodomain ProteinsHumansHypoxia-Inducible Factor 1, alpha SubunitTranscription FactorsTriple Negative Breast NeoplasmsHIF1A protein, humanHomeodomain ProteinsHypoxia-Inducible Factor 1, alpha SubunitTranscription FactorsZHX2 protein, humancancer biologyhif 1alphahumantriple negative breast cancerVHLZHX2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.