Evidence map›Paper›PMID 34779751›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Use of Fractional Exhaled Nitric Oxide to Guide the Treatment of Asthma: An Official American Thoracic Society Clinical Practice Guideline.

Sumita B Khatri, Jonathan M Iaccarino, Amisha Barochia, Israa Soghier, Praveen Akuthota, Anna Brady, Ronina A Covar, Jason S Debley, Zuzana Diamant, Anne M Fitzpatrick and 12 more

Registry-linked trialAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06705764 (Tezepelumab in the Treatment of Emergency Room Asthma in Adults), which is not on this map. Cited by 70 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06705764 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Tezepelumab in the Treatment of Emergency Room Asthma in Adults (TERAA): A Phase 4 Double-Blinded, Parallel-Group, Randomized Control Trial With an Open Label Extension

TypeinterventionalSponsorUniversity of AlbertaRan2026 to 2026Enrolled100ConditionsSevere AsthmaArmsTezepelumab, Placebo
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. The Global Airways Unit: A Multidisciplinary Strategy for Early Diagnosis and Comorbidity Detection.World journal of otorhinolaryngology - head and neck surgery · 2026
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Unrecognized ciliary motility disorders in neutrophilic severe asthma exacerbations.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
    Article
  14. Article
  15. Review
  16. Asthma: onset at young, persist when grow up.Translational pediatrics · 2026
    Review
  17. Article
  18. Article
  19. Article
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Jonathan M IaccarinoORCID 0000-0002-8119-4788
Anna Brady
Anne M FitzpatrickORCID 0000-0002-2933-5926
Nicholas J KenyonORCID 0000-0001-8839-4400
Elena K Schneider-FutschikORCID 0000-0001-6044-4824
Christine A SorknessORCID 0000-0003-2382-569X
Teal S HallstrandORCID 0000-0002-5059-6872
American Thoracic Society Assembly on Allergy, Immunology, and Inflammation

Funding

Project 3 - Personalized cystic fibrosis treatment strategies with synergistic therapies Identified in vitro.P01HL128192 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN · 2016 to 2020
$12.2M
Immunopathology of Indirect Airway Hyperresponsiveness in AsthmaK24AI130263 · NIAID · UNIVERSITY OF WASHINGTON · PI Teal S Hallstrand · 2017 to 2026
$1.3M
NHLBI NIH HHS P01 HL128192NIAID NIH HHS K24 AI130263
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Practice Guidelines as TopicAdrenal Cortex HormonesAnti-Asthmatic AgentsAsthmaHumansNitric OxideUnited StatesAdrenal Cortex HormonesAnti-Asthmatic AgentsNitric Oxideairway diseaseasthmainhaled steroidsnitric oxidetype 2 inflammation

Identifiers

PMID34779751
PMCPMC8759314

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.