Evidence map›Paper›PMID 34779488›Full record

ArticleInternational journal of molecular medicine2022

circPhc3 sponging microRNA‑93‑3p is involved in the regulation of chondrocyte function by mechanical instability in osteoarthritis.

Zhiyuan Wang, Zhitao Rao, Xin Wang, Chao Jiang, Yi Yang

Open access · hybridAbstract read
In one paragraph

Article in International journal of molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Cartilage Homeostasis and Osteoarthritis.International journal of molecular sciences · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Zhiyuan WangDepartment of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, P.R. China.
Zhitao RaoDepartment of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, P.R. China.
Xin WangDepartment of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, P.R. China.
Chao JiangDepartment of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, P.R. China.
Yi YangDepartment of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, P.R. China.
Tongji Hospital · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cartilage extracellular matrix (ECM) metabolism disorder caused by mechanical instability is a leading cause of osteoarthritis (OA), but the exact mechanisms have not been fully elucidated. Recent studies have suggested an important role of circular RNAs (circRNAs/circs) in OA. The present study aimed to investigate whether circRNAs might have a role in mechanical instability‑regulated chondrocyte matrix metabolism in OA. The expression levels of circPhc3 in human and mouse OA cartilage samples were measured using reverse transcription‑quantitative PCR and fluorescence

Indexed as

AdultAgedAnimalsBiomechanical PhenomenaChondrocytesExtracellular MatrixFemaleForkhead Box Protein O1HumansIn Situ Hybridization, FluorescenceMaleMiceMice, Inbred C57BLMicroRNAsMiddle AgedOsteoarthritisForkhead Box Protein O1Foxo1 protein, mouseMicroRNAsMIRN93 microRNA, humanRNA, Circularchondrocytescircular RNA Phc3extracellular matrix metabolismmechanical instabilityosteoarthritis

Identifiers

PMID34779488
PMCPMC8612303
OpenAlexW3212873373

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.