Evidence map›Paper›PMID 34779441›Full record

ArticleJournal of visualized experiments : JoVE2021

Open-source Toolkit: Benchtop Carbon Fiber Microelectrode Array for Nerve Recording.

Julianna M Richie, Paras R Patel, Elissa J Welle, Tianshu Dong, Lei Chen, Albert J Shih, Cynthia A Chestek

Open access · greenAbstract readVideo-Audio Media
In one paragraph

Article in Journal of visualized experiments : JoVE, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Fabrication and Validation of Sub-Cellular Carbon Fiber Electrodes.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Julianna M RichieDepartment of Biomedical Engineering, University of Michigan, Ann Arbor.
Paras R PatelDepartment of Biomedical Engineering, University of Michigan, Ann Arbor.
Elissa J WelleDepartment of Biomedical Engineering, University of Michigan, Ann Arbor.
Tianshu DongDepartment of Mechanical Engineering, University of Michigan, Ann Arbor.
Lei ChenDepartment of Mechanical Engineering, University of Massachusetts Lowell.
Albert J ShihDepartment of Mechanical Engineering, University of Michigan, Ann Arbor.
Cynthia A ChestekDepartment of Biomedical Engineering, University of Michigan, Ann Arbor; Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor; Neuroscience Graduate Program, University of Michigan, Ann Arbor; Robotics Graduate Program, University of Michigan, Ann Arbor; cchestek@umich.edu.
University of Michigan–Ann Arbor · USUniversity of Massachusetts Lowell · US

Funding

Optimization and distribution of high density cellular scale carbon and silicon arraysUF1NS107659 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHESTEK, CYNTHIA ANNE · 2018 to 2018
$3.4M
Circuit dynamics of sensorimotor integration and decision making in octopusUF1NS115817 · NINDS · MICHIGAN STATE UNIVERSITY · PI PELLED, GALIT · 2020 to 2020
$2.3M
NINDS NIH HHS UF1 NS107659NINDS NIH HHS UF1 NS115817
6 · The paper itself

Abstract

Conventional peripheral nerve probes are primarily fabricated in a cleanroom, requiring the use of multiple expensive and highly specialized tools. This paper presents a cleanroom "light" fabrication process of carbon fiber neural electrode arrays that can be learned quickly by an inexperienced cleanroom user. This carbon fiber electrode array fabrication process requires just one cleanroom tool, a Parylene C deposition machine, that can be learned quickly or outsourced to a commercial processing facility at marginal cost. This fabrication process also includes hand-populating printed circuit boards, insulation, and tip optimization. The three different tip optimizations explored here (Nd:YAG laser, blowtorch, and UV laser) result in a range of tip geometries and 1 kHz impedances, with blowtorched fibers resulting in the lowest impedance. While previous experiments have proven laser and blowtorch electrode efficacy, this paper also shows that UV laser-cut fibers can record neural signals in vivo. Existing carbon fiber arrays either do not have individuated electrodes in favor of bundles or require cleanroom fabricated guides for population and insulation. The proposed arrays use only tools that can be used at a benchtop for fiber population. This carbon fiber electrode array fabrication process allows for quick customization of bulk array fabrication at a reduced price compared to commercially available probes.

Indexed as

CarbonPeripheral NervesCarbon FiberElectric ImpedanceElectrodes, ImplantedMicroelectrodesCarbonCarbon Fiber

Identifiers

PMID34779441
PMCPMC10771276
OpenAlexW3209878161

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.