ArticleeLife2021
Ripples reflect a spectrum of synchronous spiking activity in human anterior temporal lobe.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 49 citations in OpenAlex.
- Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations.Nature neuroscience · 2026Article
- Human hippocampal ripples tune cortical responses based on predicted uncertainty.Nature neuroscience · 2026Article
- Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026Article
- A Conserved Mammalian Hippocampal Navigation Motif Reconfigured for Primate Vision.bioRxiv : the preprint server for biology · 2026Article
- Global coincident bursts of high frequency oscillations across the human cortex coordinate large-scale memory processing.Nature communications · 2026Article
- High-frequency bursts facilitate fast communication for human spatial attention.Nature neuroscience · 2026Article
- A State-Space Framework for Causal Detection of Hippocampal Ripple-Replay Events.IEEE transactions on bio-medical engineering · 2026Article
- Spatiotemporal patterns differentiate hippocampal sharp-wave ripples from interictal epileptiform discharges in mice and humans.Nature communications · 2025Article
- Ripple contributions to human memory: making the spiking content count.Nature reviews. Neuroscience · 2025Review
- Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations.bioRxiv : the preprint server for biology · 2025Article
- Physical activity simultaneously improves working memory and ripple-spindle coupling.Communications biology · 2025Article
- Motifs of human high-frequency oscillations structure processing and memory of continuous audiovisual narratives.Science advances · 2025Article
- Movie-watching evokes ripple-like activity within events and at event boundaries.Nature communications · 2025Article
- Hippocampal and cortical high-frequency oscillations orchestrate human semantic networks during word list memory.iScience · 2025Article
- Attention to memory content enhances single-unit spike sequence fidelity in the human anterior temporal lobe.Current biology : CB · 2025Article
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- Binding of cortical functional modules by synchronous high-frequency oscillations.Nature human behaviour · 2024Article
- High frequency oscillations in human memory and cognition: a neurophysiological substrate of engrams?Brain : a journal of neurology · 2024Review
- Focal seizures induce spatiotemporally organized spiking activity in the human cortex.Nature communications · 2024Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Direct brain recordings have provided important insights into how high-frequency activity captured through intracranial EEG (iEEG) supports human memory retrieval. The extent to which such activity is comprised of transient fluctuations that reflect the dynamic coordination of underlying neurons, however, remains unclear. Here, we simultaneously record iEEG, local field potential (LFP), and single unit activity in the human temporal cortex. We demonstrate that fast oscillations within the previously identified 80-120 Hz ripple band contribute to broadband high-frequency activity in the human cortex. These ripple oscillations exhibit a spectrum of amplitudes and durations related to the amount of underlying neuronal spiking. Ripples in the macro-scale iEEG are related to the number and synchrony of ripples in the micro-scale LFP, which in turn are related to the synchrony of neuronal spiking. Our data suggest that neural activity in the human temporal lobe is organized into transient bouts of ripple oscillations that reflect underlying bursts of spiking activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.