Trial reportJournal of the American Heart Association2021
Assessment of Impact of Patient Recruitment Volume on Risk Profile, Outcomes, and Treatment Effect in a Randomized Trial of Ticagrelor Versus Prasugrel in Acute Coronary Syndromes.
Trial report in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
Gjin NdrepepaDeutsches Herzzentrum München, Cardiology and Technische Universität München Munich Germany.
Franz-Josef NeumannDepartment of Cardiology and Angiology II University Heart Center Freiburg Bad Krozingen Bad Krozingen Germany.ORCID 0000-0002-0921-8351
Maurizio MenichelliDepartment of Cardiology Ospedale Fabrizio Spaziani Frosinone Italy.
Isabell BernlochnerMedizinische Klinik und Poliklinik Innere Medizin I (Kardiologie, Angiologie, Pneumologie), Klinikum rechts der Isar Munich Germany.ORCID 0000-0002-0981-839X
Gert RichardtHeart Center Bad Segeberg Bad Segeberg Germany.
Jochen WöhrleDepartment of Cardiology Medical Campus Lake Constance Friedrichshafen Germany.ORCID 0000-0003-4438-992X
Bernhard WitzenbichlerDepartment of Cardiology and Pneumology Helios Amper-Klinikum Dachau Dachau Germany.ORCID 0000-0001-9322-1926
Katharina MayerDeutsches Herzzentrum München, Cardiology and Technische Universität München Munich Germany.
Salvatore CasseseDeutsches Herzzentrum München, Cardiology and Technische Universität München Munich Germany.ORCID 0000-0002-8668-4313
Senta GewaltDeutsches Herzzentrum München, Cardiology and Technische Universität München Munich Germany.ORCID 0000-0001-6273-4171
Erion XhepaDeutsches Herzzentrum München, Cardiology and Technische Universität München Munich Germany.ORCID 0000-0002-0728-2819
Sebastian KufnerDeutsches Herzzentrum München, Cardiology and Technische Universität München Munich Germany.
Hendrik B SagerDeutsches Herzzentrum München, Cardiology and Technische Universität München Munich Germany.ORCID 0000-0002-0197-6553
Michael JonerDeutsches Herzzentrum München, Cardiology and Technische Universität München Munich Germany.ORCID 0000-0002-2971-8310
Tareq IbrahimMedizinische Klinik und Poliklinik Innere Medizin I (Kardiologie, Angiologie, Pneumologie), Klinikum rechts der Isar Munich Germany.ORCID 0000-0003-3321-2969
Karl-Ludwig LaugwitzMedizinische Klinik und Poliklinik Innere Medizin I (Kardiologie, Angiologie, Pneumologie), Klinikum rechts der Isar Munich Germany.ORCID 0000-0003-4948-4846
Heribert SchunkertDeutsches Herzzentrum München, Cardiology and Technische Universität München Munich Germany.ORCID 0000-0001-6428-3001
Stefanie SchüpkeDeutsches Herzzentrum München, Cardiology and Technische Universität München Munich Germany.
Adnan KastratiDeutsches Herzzentrum München, Cardiology and Technische Universität München Munich Germany.ORCID 0000-0003-4341-891X
Deutsches Herzzentrum München · DEGerman Centre for Cardiovascular Research · DETUM Klinikum · DEHelios Amper-Klinikum Dachau · DEOspedale degli Infermi · ITSegeberger Kliniken · DEUniversitäts-Herzzentrum Freiburg-Bad Krozingen · DE
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
BACKGROUND Whether there are differences in the risk profile and treatment effect in patients recruited in a low recruitment center (LRC) versus patients recruited in a high recruitment center (HRC) in a randomized multicenter trial remains unknown. METHODS AND RESULTS This study included 4018 patients with acute coronary syndrome recruited in the ISAR-REACT 5 (Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment 5) trial. The primary end point was a composite of all-cause death, myocardial infarction, or stroke. Overall, 3011 patients (75%) were recruited in the HRCs (7 centers recruiting 258 to 628 patients; median, 413 patients) and 1007 patients (25%) were recruited in the LRCs (16 centers recruiting 5 to 201 patients; median, 52 patients). Patients recruited in the LRCs had more favorable cardiovascular risk profiles than patients recruited in the HRCs. The primary end point occurred in 72 patients in the LRCs and 249 patients in the HRCs (cumulative incidence, 7.3% and 8.4%;
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Assessment of Impact of Patient Recruitment Volume on Risk Profile, Outcomes, and Treatment Effect in a Randomized Trial of Ticagrelor Versus Prasugrel in Acute Coronary Syndromes. · full record | OpenQuestion