ArticleAndrology2022
A higher preconceptional paternal body mass index influences fertilization rate and preimplantation embryo development.
Article in Andrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Paternal preconception modifiable risk factors for adverse pregnancy and offspring outcomes: a review of contemporary evidence from observational studies.BMC public health · 2023Pooled it
- The Preconception Health and Health Behaviors of Australian First-Time Fathers: A Cross-Sectional Study.Health education & behavior : the official publication of the Society for Public Health Education · 2026Article
- Cohort Profile Update: the Rotterdam Periconceptional Cohort-biomarkers, lifestyle intervention, and artificial intelligence.International journal of epidemiology · 2026Article
- Clinical Implications of Paternal Age in Assisted Reproduction: Integrating Sperm Epigenetic Evidence.Journal of clinical medicine · 2026Review
- Article
- Parental dietary patterns and assisted reproductive technology outcomes including embryo morphokinetics: rotterdam periconception cohort.Journal of assisted reproduction and genetics · 2025Article
- Impact of male factors on morphokinetic parameters: a prospective analysis using time-lapse monitored embryos.Journal of assisted reproduction and genetics · 2025Observational
- Adverse effects of maternal and paternal body mass index on assisted reproductive techniques outcomes: A time-lapse study.Clinical and experimental reproductive medicine · 2025Article
- The Istanbul consensus update: a revised ESHRE/ALPHA consensus on oocyte and embryo static and dynamic morphological assessment†,‡.Human reproduction (Oxford, England) · 2025Article
- Reply: Unveiling early predictors of adverse birth outcomes: the potential and limits of embryonic growth metrics.Human reproduction (Oxford, England) · 2025Article
- Impact of paternal high energy diets on semen quality and embryo development in cattle.Reproduction & fertility · 2025Review
- Pregnancy intention, preconception health, health behaviours, and information and health advice seeking among expectant male partners.BMC primary care · 2025Article
- Environmental Stress-Induced Alterations in Embryo Developmental Morphokinetics.Journal of xenobiotics · 2024Review
- Paternal undernutrition and overnutrition modify semen composition and preimplantation embryo developmental kinetics in mice.BMC biology · 2024Article
- Preconception and Early-Pregnancy Body Mass Index in Women and Men, Time to Pregnancy, and Risk of Miscarriage.JAMA network open · 2024Article
- Review
- Effect of Paternal Body Mass Index onThe world journal of men's health · 2024Article
- Human oocyte area is associated with preimplantation embryo usage and early embryo development: the Rotterdam Periconception Cohort.Journal of assisted reproduction and genetics · 2023Article
- A higher preconceptional paternal body mass index influences fertilization rate and preimplantation embryo development.Andrology · 2022Article
- Abnormal BMI in Male and/or Female Partners Are Deleterious for Embryonic Development and Pregnancy Outcome During ART Process: A Retrospective Study.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is a worldwide problem affecting the health of millions of people throughout the life course. Studies reveal that obesity impairs sperm parameters and epigenetics, potentially influencing embryonic development.
objectiveTo investigate the association between preconceptional paternal body mass index (BMI) and embryo morphokinetics using a time-lapse incubator and in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) outcomes. MATERIALS AND
methodsParticipants were recruited from a tertiary hospital in this prospective periconceptional cohort study. A total of 211 men were included: 86 with normal weight (BMI < 25.0), 94 overweight (BMI 25-29.9), and 41 obese (BMI ≥ 30). These men were part of a couple that underwent IVF/ICSI treatment with ejaculated sperm after which 757 embryos were cultured in a time-lapse incubator. The main outcome parameters consisted of fertilization rate, embryo developmental morphokinetics, embryo quality assessed by a time-lapse prediction algorithm (KIDScore), and live birth rate.
resultsA higher paternal BMI was associated with faster development of the preimplantation embryo, especially during the first cleavage divisions (t2: -0.11 h (p = 0.05) and t3: -0.19 h (p = 0.01)). Embryo quality using the KIDScore was not altered. The linear regression analysis, after adjustment for confounders (paternal age, ethnicity, smoking, alcohol use, education, total motile sperm count, and maternal age and BMI), showed an inverse association between paternal BMI and fertilization rate (effect estimate: -0.01 (p = 0.002)), but not with the live birth rate. DISCUSSION AND
conclusionOur data demonstrate that a higher preconceptional paternal BMI is associated with a reduced fertilization rate in IVF/ICSI treatment. Our findings underline the importance of a healthy paternal weight during the preconception period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.