Evidence map›Paper›PMID 34778881›Full record

ReviewAnimal diseases2021

The nucleoside antiviral prodrug remdesivir in treating COVID-19 and beyond with interspecies significance.

Daisy Yan, One Hyuk Ra, Bingfang Yan

Open access · diamondAbstract readReview
In one paragraph

Review in Animal diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Daisy YanSidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut St, Philadelphia, PA 19107 USA.
One Hyuk RaDepartment of Anesthesiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 USA.
Bingfang YanDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45229 USA.ORCID 0000-0002-0798-5792
Brigham and Women's Hospital · USThomas Jefferson University · USUniversity of Cincinnati · US

Funding

Biodegradable hollow CUS nanoparticles for photothermal cancer therapyR01EB018748 · NIBIB · UNIVERSITY OF RHODE ISLAND · PI YAN, BINGFANG · 2013 to 2016
$1.3M
Metabolic basis for lipid abnormality with anti-HIV tenofovir prodrugsR21AI153031 · NIAID · UNIVERSITY OF CINCINNATI · PI YAN, BINGFANG · 2020 to 2021
$444k
NIAID NIH HHS R21 AI153031NIBIB NIH HHS R01 EB018748
6 · The paper itself

Abstract

Infectious pandemics result in hundreds and millions of deaths, notable examples of the Spanish Flu, the Black Death and smallpox. The current pandemic, caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), is unprecedented even in the historical term of pandemics. The unprecedentedness is featured by multiple surges, rapid identification of therapeutic options and accelerated development of vaccines. Remdesivir, originally developed for Ebola viral disease, is the first treatment of COVID-19 (Coronavirus disease 2019) approved by the United States Food and Drug Administration. As demonstrated by

Indexed as

Animal modelCarboxylesterasesCoronavirusCOVID-19Drug-drug interactions, interspecies differencePandemicRemdesivirSARS-CoV-2

Identifiers

PMID34778881
PMCPMC8422062
OpenAlexW3198337007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.