Evidence map›Paper›PMID 34778272›Full record

ArticleFrontiers in cell and developmental biology2021

Generation of a Spiral Ganglion Neuron Degeneration Mouse Model.

Zhengqing Hu, Fnu Komal, Aditi Singh, Meng Deng

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Targeted spiral ganglion neuron degeneration in parvalbumin-Cre neonatal mice.Molecular therapy. Methods & clinical development · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Zhengqing HuJohn D. Dingell VA Medical Center, Detroit, MI, United States.
Fnu KomalDepartment of Otolaryngology-HNS, Wayne State University School of Medicine, Detroit, MI, United States.
Aditi SinghDepartment of Otolaryngology-HNS, Wayne State University School of Medicine, Detroit, MI, United States.
Meng DengDepartment of Otolaryngology-HNS, Wayne State University School of Medicine, Detroit, MI, United States.
Wayne State University · USJohn D. Dingell VA Medical Center · US

Funding

RRD VA I01 RX002100
6 · The paper itself

Abstract

Spiral ganglion neurons (SGNs) can be injured by a wide variety of insults. However, there still is a lack of degeneration models to specifically damage the SGNs without disturbing other types of cells in the inner ear. This study aims to generate an SGN-specific damage model using the Cre-LoxP transgenic mouse strains. The Cre-inducible diphtheria toxin receptor (

Indexed as

auditory brainstem responseCre-LoxPdegenerationiDTRneurofilamentspiral ganglion

Identifiers

PMID34778272
PMCPMC8578993
OpenAlexW3208677239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.