Evidence map›Paper›PMID 34778257›Full record

ArticleFrontiers in cell and developmental biology2021

Cardiac Fibroblast Growth Factor 23 Excess Does Not Induce Left Ventricular Hypertrophy in Healthy Mice.

Maren Leifheit-Nestler, Miriam A Wagner, Beatrice Richter, Corinna Piepert, Fiona Eitner, Ineke Böckmann, Isabel Vogt, Andrea Grund, Susanne S Hille, Ariana Foinquinos and 4 more

Abstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. FGF23 - A hormone produced by bone and has many faces.Reviews in endocrine & metabolic disorders · 2026
    Review
  2. High Phosphate Load Induces De Novo Formation of Tertiary Lymphoid Structures in the Kidney.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  3. Review
  4. Article
  5. FGF-based drug discovery: advances and challenges.Nature reviews. Drug discovery · 2025
    Review
  6. Article
  7. Review
  8. Review
  9. The regulation of FGF23 under physiological and pathophysiological conditions.Pflugers Archiv : European journal of physiology · 2022
    Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maren Leifheit-NestlerDepartment of Pediatric Kidney, Liver and Metabolic Diseases, Pediatric Research Center, Hannover Medical School, Hanover, Germany.
Miriam A WagnerDepartment of Pediatric Kidney, Liver and Metabolic Diseases, Pediatric Research Center, Hannover Medical School, Hanover, Germany.
Beatrice RichterDepartment of Pediatric Kidney, Liver and Metabolic Diseases, Pediatric Research Center, Hannover Medical School, Hanover, Germany.
Corinna PiepertDepartment of Pediatric Kidney, Liver and Metabolic Diseases, Pediatric Research Center, Hannover Medical School, Hanover, Germany.
Fiona EitnerDepartment of Pediatric Kidney, Liver and Metabolic Diseases, Pediatric Research Center, Hannover Medical School, Hanover, Germany.
Ineke BöckmannDepartment of Pediatric Kidney, Liver and Metabolic Diseases, Pediatric Research Center, Hannover Medical School, Hanover, Germany.
Isabel VogtDepartment of Pediatric Kidney, Liver and Metabolic Diseases, Pediatric Research Center, Hannover Medical School, Hanover, Germany.
Andrea GrundDepartment of Pediatric Kidney, Liver and Metabolic Diseases, Pediatric Research Center, Hannover Medical School, Hanover, Germany.
Susanne S HilleDepartment of Internal Medicine III, University Hospital Kiel, Kiel, Germany.
Ariana FoinquinosInstitute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hanover, Germany.
Karina ZimmerInstitute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hanover, Germany.
Thomas ThumInstitute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hanover, Germany.
Oliver J MüllerDepartment of Internal Medicine III, University Hospital Kiel, Kiel, Germany.
Dieter HaffnerDepartment of Pediatric Kidney, Liver and Metabolic Diseases, Pediatric Research Center, Hannover Medical School, Hanover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibroblast growth factor (FGF) 23 is elevated in chronic kidney disease (CKD) to maintain phosphate homeostasis. FGF23 is associated with left ventricular hypertrophy (LVH) in CKD and induces LVH

Indexed as

FGF23fibrosisklotholeft ventricular hypertrophymineral metabolismmouse model

Identifiers

PMID34778257
PMCPMC8581397

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.