Evidence map›Paper›PMID 34778252›Full record

ReviewFrontiers in cell and developmental biology2021

The Emerging Role of Exosomes in Cancer Chemoresistance.

Jing Li, Na Gao, Zhengfan Gao, Wei Liu, Bairen Pang, Xingli Dong, Yong Li, Tianli Fan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Research on exosomes in cancer multidrug resistance and clinical translation.Extracellular vesicles and circulating nucleic acids · 2026
    Review
  5. Review
  6. Article
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  9. Article
  10. Article
  11. Article
  12. Review
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  18. Article
  19. Harnessing cancer stem cell-derived exosomes to improve cancer therapy.Journal of experimental & clinical cancer research : CR · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jing LiDepartment of Pharmacology, School of Basic Medical Science, Zhengzhou University, Zhengzhou, China.
Na GaoDepartment of Pharmacology, School of Basic Medical Science, Zhengzhou University, Zhengzhou, China.
Zhengfan GaoDepartment of Pharmacology, School of Basic Medical Science, Zhengzhou University, Zhengzhou, China.
Wei LiuDepartment of Pharmacology, School of Basic Medical Science, Zhengzhou University, Zhengzhou, China.
Bairen PangSt George Hospital, St George and Sutherland Clinical School, Faculty of Medicine, UNSW Sydney, Kensington, NSW, Australia.
Xingli DongDepartment of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin, China.
Yong LiDepartment of Pharmacology, School of Basic Medical Science, Zhengzhou University, Zhengzhou, China.
Tianli FanDepartment of Pharmacology, School of Basic Medical Science, Zhengzhou University, Zhengzhou, China.
Zhengzhou University · CNUNSW Sydney · AUHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemoresistance is an impending challenge in cancer treatment. In recent years, exosomes, a subtype of extracellular vesicles with a diameter of 40-150 nm in bloodstream and other bio-fluids, have attracted increasing interest. Exosomes contain proteins, nucleic acids, and lipids, which act as important signaling molecules. Many reports indicate that exosomes play critical roles in chemoresistance through intercellular interactions, including drug removal from cells, transfer of drug resistance phenotypes to other cancer cells, and the increase in plastic stem cell subsets. Exosomes can reflect the physiological and pathological state of parent cells. Owing to their elevated stability, specificity, and sensitivity, exosomes are served as biomarkers in liquid biopsies to monitor cancer chemoresistance, progression, and recurrence. This review summarizes the exosome-mediated mechanisms of cancer chemoresistance, as well as its role in reversing and monitoring chemoresistance. The scientific and technological challenges and future applications of exosomes are also explored.

Indexed as

biomarkercancerchemoresistanceexosomeliquid biopsy

Identifiers

PMID34778252
PMCPMC8581179
OpenAlexW3209778108

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.