Evidence map›Paper›PMID 34778249›Full record

ArticleFrontiers in cell and developmental biology2021

The Novel Positive Allosteric Modulator of the GABA

Paola Maccioni, Katarzyna Kaczanowska, Harshani Lawrence, Sang Yun, Jessica Bratzu, Gian Luigi Gessa, Patricia McDonald, Giancarlo Colombo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. GABAMedComm · 2025
    Review
  3. Review
  4. Delving into the reducing effects of the GABAAlcohol (Fayetteville, N.Y.) · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Paola MaccioniNeuroscience Institute, Section of Cagliari, National Research Council of Italy, Monserrato, Italy.
Katarzyna KaczanowskaDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA, United States.
Harshani LawrenceChemical Biology Core, Moffitt Cancer Center, Tampa, FL, United States.
Sang YunChemical Biology Core, Moffitt Cancer Center, Tampa, FL, United States.
Jessica BratzuNeuroscience Institute, Section of Cagliari, National Research Council of Italy, Monserrato, Italy.
Gian Luigi GessaNeuroscience Institute, Section of Cagliari, National Research Council of Italy, Monserrato, Italy.
Patricia McDonaldDepartment of Cancer Physiology, Moffitt Cancer Center, Tampa, FL, United States.
Giancarlo ColomboNeuroscience Institute, Section of Cagliari, National Research Council of Italy, Monserrato, Italy.
Neuroscience Institute · ITMoffitt Cancer Center · USScripps Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Positive allosteric modulators (PAMs) of the GABA

Indexed as

alcohol self-administrationcue-induced reinstatement of alcohol seekingGABAB receptorKK-92Apositive allosteric modulatorrats

Identifiers

PMID34778249
PMCPMC8585307
OpenAlexW3211021892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.