Evidence map›Paper›PMID 34778217›Full record

ReviewFrontiers in chemistry2021

Chagas Disease Drug Discovery in Latin America-A Mini Review of Antiparasitic Agents Explored Between 2010 and 2021.

Ramon G de Oliveira, Luiza R Cruz, María C Mollo, Luiz C Dias, Jadel M Kratz

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Anti-ACS omega · 2025
    Article
  2. Article
  3. Review
  4. Discovery and Early Optimization of 1Journal of medicinal chemistry · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ramon G de OliveiraLaboratory of Synthetic Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, Brazil.
Luiza R CruzLaboratory of Synthetic Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, Brazil.
María C MolloLaboratory of Synthetic Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, Brazil.
Luiz C DiasLaboratory of Synthetic Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, Brazil.
Jadel M KratzDrugs for Neglected Diseases Initiative (DNDi) Latin America, Rio de Janeiro, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease is a neglected tropical disease caused by the protozoan parasite

Indexed as

hit identificationhit to leadlead optimizationmedicinal chemistryneglected tropical diseasesscreeningTrypanosoma cruzi

Identifiers

PMID34778217
PMCPMC8581468
OpenAlexW3209501188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.