Evidence map›Paper›PMID 34778169›Full record

ReviewFrontiers in public health2021

Knowledge Gaps in the Understanding of Antimicrobial Resistance in Canada.

Kayley D McCubbin, R Michele Anholt, Ellen de Jong, Jennifer A Ida, Diego B Nóbrega, John P Kastelic, John M Conly, Matthias Götte, Tim A McAllister, Karin Orsel and 17 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
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  8. Article
  9. Article
  10. Review
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  12. Review
  13. Livestock Antibiotics Use and Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2025
    Review
  14. Article
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  16. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Kayley D McCubbinDepartment of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
R Michele AnholtOne Health at UCalgary, University of Calgary, Calgary, AB, Canada.
Ellen de JongDepartment of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Jennifer A IdaDepartment of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Diego B NóbregaDepartment of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
John P KastelicDepartment of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
John M ConlyOne Health at UCalgary, University of Calgary, Calgary, AB, Canada.
Matthias GötteDepartment of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Tim A McAllisterAgriculture and Agri-Food Canada, Lethbridge Research Centre, Lethbridge, AB, Canada.
Karin OrselDepartment of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Ian LewisOne Health at UCalgary, University of Calgary, Calgary, AB, Canada.
Leland JacksonOne Health at UCalgary, University of Calgary, Calgary, AB, Canada.
Graham PlastowDepartment of Agricultural, Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, AB, Canada.
Hans-Joachim WiedenDepartment of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, AB, Canada.
Kathy McCoyOne Health at UCalgary, University of Calgary, Calgary, AB, Canada.
Myles LeslieOne Health at UCalgary, University of Calgary, Calgary, AB, Canada.
Joan L RobinsonDepartment of Pediatrics, Faculty of Medicine, University of Alberta, Edmonton, AB, Canada.
Lorian HardcastleOne Health at UCalgary, University of Calgary, Calgary, AB, Canada.
Aidan HollisOne Health at UCalgary, University of Calgary, Calgary, AB, Canada.
Nicholas J AshboltFaculty of Science and Engineering, Southern Cross University, Lismore, NSW, Australia.
Sylvia CheckleyOne Health at UCalgary, University of Calgary, Calgary, AB, Canada.
Gregory J TyrrellAlberta Precision Laboratories, Alberta Health Services, Calgary, AB, Canada.
André G BuretOne Health at UCalgary, University of Calgary, Calgary, AB, Canada.
Elissa Rennert-MayOne Health at UCalgary, University of Calgary, Calgary, AB, Canada.
Ellen GoddardDepartment of Resource Economics and Environmental Sociology, Faculty of Agriculture, Life and Environmental Science, University of Alberta, Edmonton, AB, Canada.
Simon J G OttoHEAT-AMR Research Group, School of Public Health, University of Alberta, Edmonton, AB, Canada.
Herman W BarkemaDepartment of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current limitations in the understanding and control of antimicrobial resistance (AMR) in Canada are described through a comprehensive review focusing on: (1) treatment optimization; (2) surveillance of antimicrobial use and AMR; and (3) prevention of transmission of AMR. Without addressing gaps in identified areas, sustained progress in AMR mitigation is unlikely. Expert opinions and perspectives contributed to prioritizing identified gaps. Using Canada as an example, this review emphasizes the importance and necessity of a One Health approach for understanding and mitigating AMR. Specifically, antimicrobial use in human, animal, crop, and environmental sectors cannot be regarded as independent; therefore, a One Health approach is needed in AMR research and understanding, current surveillance efforts, and policy. Discussions regarding addressing described knowledge gaps are separated into four categories: (1) further research; (2) increased capacity/resources; (3) increased prescriber/end-user knowledge; and (4) policy development/enforcement. This review highlights the research and increased capacity and resources to generate new knowledge and implement recommendations needed to address all identified gaps, including economic, social, and environmental considerations. More prescriber/end-user knowledge and policy development/enforcement are needed, but must be informed by realistic recommendations, with input from all relevant stakeholders. For most knowledge gaps, important next steps are uncertain. In conclusion, identified knowledge gaps underlined the need for AMR policy decisions to be considered in a One Health framework, while highlighting critical needs to achieve realistic and meaningful progress.

Indexed as

Anti-Infective AgentsOne HealthAnimalsAnti-Bacterial AgentsDrug Resistance, BacterialHealth PolicyHumansAnti-Bacterial AgentsAnti-Infective Agentsantimicrobial resistanceantimicrobial stewardshipCanadaknowledge gapsOne Healthpolicy

Identifiers

PMID34778169
PMCPMC8582488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.