Evidence map›Paper›PMID 34778119›Full record

ArticleFrontiers in pediatrics2021

Case Report: Haploidentical Bone Marrow Transplantation in Two Brothers With Wiskott-Aldrich Syndrome Using Their Father as the Donor.

Jasmine Smith, Jessica Hass Alfonso, Naresh Reddivalla, Pablo Angulo, Emmanuel Katsanis

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jasmine SmithDepartment of Pediatrics, University of Arizona, Tucson, AZ, United States.
Jessica Hass AlfonsoDepartment of Pediatrics, University of Arizona, Tucson, AZ, United States.
Naresh ReddivallaDepartment of Pediatrics, University of Arizona, Tucson, AZ, United States.
Pablo AnguloDepartment of Pediatrics, University of Arizona, Tucson, AZ, United States.
Emmanuel KatsanisDepartment of Pediatrics, University of Arizona, Tucson, AZ, United States.
Banner Desert Medical Center · USBanner - University Medical Center Tucson · USUniversity of Arizona Cancer Center

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wiskott-Aldrich syndrome (WAS) is an X-linked genetic disorder with a variable phenotypic expression that includes thrombocytopenia, eczema, and immunodeficiency. Some patients may also exhibit autoimmune manifestations. Patients with WAS are at increased risk of developing malignancies such as lymphoma. Allogeneic hematopoietic cell transplantation remains the only curative treatment. Haploidentical bone marrow transplantation (haplo-BMT) with post-transplant cyclophosphamide (PT-CY) has more recently been applied in WAS. Here, we report two brothers who underwent successful T-cell replete haplo-BMT with PT-CY at ages 9 months and 4 years using their father as the donor. Our myeloablative regimen was well-tolerated with minimal organ toxicity and no acute or chronic graft vs. host disease (GvHD). Haplo-BMT may be considered as a safe and effective option for patients with WAS who do not have available human leukocyte antigen (HLA) matched donors.

Indexed as

cyclophosphamidehaploidentical hematopoietic stem cell transplantationimmunodeficiencymyeloablative allogeneic hematopoietic cell transplantationWiskott Aldrich syndrome (WAS)

Identifiers

PMID34778119
PMCPMC8578118
OpenAlexW3209681379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.