Evidence map›Paper›PMID 34778104›Full record

ArticleFrontiers in cellular and infection microbiology2021

Rahwa Taddese, Rian Roelofs, Derk Draper, Xinqun Wu, Shaoguang Wu, Dorine W Swinkels, Harold Tjalsma, Annemarie Boleij

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

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  9. Factors underlying the association betweenGut microbiome (Cambridge, England) · 2024
    Review
  10. Association of theOpen forum infectious diseases · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Rahwa TaddeseDepartment of Pathology, Nijmegen Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Centre (Radboudumc), Nijmegen, Netherlands.
Rian RoelofsLaboratory Medicine, Nijmegen Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Centre (Radboudumc), Nijmegen, Netherlands.
Derk DraperDepartment of Pathology, Nijmegen Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Centre (Radboudumc), Nijmegen, Netherlands.
Xinqun WuDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University, Baltimore, MD, United States.
Shaoguang WuDepartment of Medicine, Division of Infectious Diseases, Johns Hopkins University, Baltimore, MD, United States.
Dorine W SwinkelsLaboratory Medicine, Nijmegen Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Centre (Radboudumc), Nijmegen, Netherlands.
Harold TjalsmaLaboratory Medicine, Nijmegen Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Centre (Radboudumc), Nijmegen, Netherlands.
Annemarie BoleijDepartment of Pathology, Nijmegen Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Centre (Radboudumc), Nijmegen, Netherlands.
Radboud Institute for Molecular Life Sciences · NLJohns Hopkins University · USRadboud University Nijmegen · NLRadboud University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The opportunistic pathogen Design and Results: Transcription profiling of Conclusion: This study shows that gut bacteria have the potential to modulate the expression of biotransformation pathways in colonic epithelial cells in an AhR-dependent manner. This offers a novel theory on the contribution of intestinal bacteria to the etiology of CRC by modifying the capacity of intestinal epithelial or (pre-)cancerous cells to (de)toxify dietary components, which could alter intestinal susceptibility to DNA damaging events.

Indexed as

Colorectal NeoplasmsStreptococcus gallolyticusAnimalsBiotransformationCytochrome P-450 CYP1A1Epithelial CellsMiceMice, Inbred C57BLReceptors, Aryl HydrocarbonCyp1a1 protein, mouseCytochrome P-450 CYP1A1Receptors, Aryl HydrocarbonAryl hydrocarbon (Ah) receptorbiotransformationcolorectal cancergut microbiotaStreptococcus gallolyticus

Identifiers

PMID34778104
PMCPMC8579041
OpenAlexW3209046384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.