Evidence map›Paper›PMID 34777921›Full record

ReviewCurrent dermatology reports2021

Updates and Insights in the Diagnosis and Management of DRESS Syndrome.

Elisa Maria Schunkert, Sherrie Jill Divito

Open access · bronzeAbstract readReview
In one paragraph

Review in Current dermatology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 72 citations in OpenAlex.

  1. [Research advances on the role of eosinophils in acute liver injury].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  2. Article
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  7. DRESS Syndrome - Rare but Potentially Fatal Drug Reaction.Hawai'i journal of health & social welfare · 2025
    Article
  8. Review
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  11. Review
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  18. Review
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  20. A Case of Olanzapine-Induced Cutaneous Eruption.The American journal of case reports · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elisa Maria SchunkertDepartment of Dermatology, Brigham & Women's Hospital, Harvard Medical School, 221 Longwood Ave, EBRC Rm 513, Boston, MA 02115 USA.ORCID 0000-0002-4388-8420
Sherrie Jill DivitoDepartment of Dermatology, Brigham & Women's Hospital, Harvard Medical School, 221 Longwood Ave, EBRC Rm 513, Boston, MA 02115 USA.
Brigham and Women's Hospital · US

Funding

Investigating a novel cell population in delayed-onset drug hypersensitivity reactionsDP5OD023091 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI DIVITO, SHERRIE JILL · 2016 to 2020
$2.1M
Investigating mechanisms of epidermal cell death in Toxic Epidermal NecrolysisR21AI150657 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI DIVITO, SHERRIE JILL · 2020 to 2021
$492k
Adoption of Pharmacotherapy in Alcoholism TreatmentR21AA015065 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MILLER, PETER M · 2004 to 2005
$383k
NIAAA NIH HHS R21 AA015065NIAID NIH HHS R21 AI150657NIH HHS DP5 OD023091
6 · The paper itself

Abstract

purpose of reviewTo provide updates on recent advances in the diagnosis and management of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. RECENT

findingsThe number of identified HLA allele associations with DRESS continues to grow. There is increasing evidence indicating viral infection, reactivation, and cross-reactivity may play key roles in disease. Translational work illuminated JAK/STAT activation in recalcitrant disease. There is expanding recognition of rapid-onset DRESS resulting from specific drugs. SUMMARY: DRESS is a severe form of adverse drug reaction with potential for significant morbidity and mortality. Recent research advances may improve clinical care. HLA screening can now be performed to prevent disease in susceptible patients and may help identify culprit drugs in the near future. Viral testing should be performed on every patient, and if positive, patients potentially treated with antiviral therapy. JAK inhibitors may be an effective treatment option for DRESS. Early onset of disease relative to drug exposure should not exclude the diagnosis of DRESS.

Indexed as

Culprit drugDelayed-type drug hypersensitivity reactionsDrug reactionsDrug reaction with eosinophilia and systemic symptoms (DRESS)RegiSCARSCARs

Identifiers

PMID34777921
PMCPMC8577395
OpenAlexW3212727911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.