Evidence map›Paper›PMID 34777920›Full record

ArticleOncoimmunology2021

PD-1 blockade improves the anti-tumor potency of exhausted CD3

Longxiang Tao, Shanshan Wang, Guijie Kang, Shanyue Jiang, Wenwei Yin, Lu Zong, Jing Li, Xuefu Wang

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 37 citations in OpenAlex.

  1. The role of PD‑1/PD‑L1 axis in liver diseases.Clinical and experimental medicine · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy.Clinical reviews in allergy & immunology · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Natural Killer T-like Cells: Immunobiology and Role in Disease.International journal of molecular sciences · 2023
    Review
  14. Article
  15. Article
  16. Review
  17. Dysfunction of circulating CD3International journal of medical sciences · 2023
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Longxiang TaoInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, Anhui, China.
Shanshan WangInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, Anhui, China.
Guijie KangInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, Anhui, China.
Shanyue JiangInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, Anhui, China.
Wenwei YinDepartment of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Lu ZongDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Jing LiDepartment of Biochemistry and Molecular Biology, School of Life Sciences, Anhui Medical University, Hefei, Anhui, China.
Xuefu WangInflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, Hefei, Anhui, China.ORCID 0000-0001-7212-7156
Anhui Medical University · CNDalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD3

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsNatural Killer T-CellsCD8-Positive T-LymphocytesHumansProgrammed Cell Death 1 ReceptorProgrammed Cell Death 1 ReceptorHepatocellular carcinomaimmune exhaustionimmunotherapynkt-like cellspd-1

Identifiers

PMID34777920
PMCPMC8583083
OpenAlexW3211419328

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.