Evidence map›Paper›PMID 34777872›Full record

ArticleEgyptian liver journal2021

Trichrome-positive intrahepatic cytoplasmic globules are potential histopathological clue for COVID-19-induced hepatitis: a case report.

Dina Sweed, Mohamed Ramadan El Shanshory, Eman Mohammed Elaskary, Hassnaa Atef Hassan, Enas Sweed, Eman Sweed, Shimaa Abdelsattar, Ahmed Abdelgawad, Asmaa Mosbeh, Heba Abdallah and 2 more

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Egyptian liver journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Dina SweedPathology Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.ORCID 0000-0001-6483-5056
Mohamed Ramadan El ShanshoryPediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Eman Mohammed ElaskaryPediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Hassnaa Atef HassanPediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Enas SweedRadiology Department, Faculty of Medicine, Benha University, Benha, Egypt.
Eman SweedClinical Pharmacology Department, Faculty of Medicine, Menoufia University, Shibin el Kom, Egypt.
Shimaa AbdelsattarClinical Pathology Department, National Liver Institute, Shibin el Kom, Egypt.
Ahmed AbdelgawadClinical Biochemistry, and Molecular Diagnostics Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Asmaa MosbehPathology Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Heba AbdallahClinical Biochemistry, and Molecular Diagnostics Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Shereen El-MashadPathology Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Nermine EhsanPathology Department, National Liver Institute, Menoufia University, Shibin el Kom, Egypt.
Menoufia University · EGTanta University · EGBenha University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection mainly affects respiratory system. Later, liver affection has also been reported in the form of marked elevated liver enzymes. However, the association of coronavirus disease-19 (COVID-19) and autoimmune diseases is not clear. CASE PRESENTATION: A female patient with a known history of autoimmune hemolytic anemia (AIHH) for which she was treated with prednisolone was admitted for uncontrolled anemia followed by fever and elevated liver enzymes. All the laboratory and radiological investigations were not typical for COVID-19 or any other etiology. Liver biopsy revealed numerous pale eosinophilic trichrome-positive intracytoplasmic globules. The pathology raised the suspicion for SARS-CoV-2-associated hepatitis, which was confirmed by a positive IgG titer. The patient showed a dramatic improvement on the maintenance dose of prednisolone.

conclusionsAIHA patients co-infected with SARS-CoV-2 may be at risk of uncontrolled disease and should continue their treatment regimen. Histopathology has a role in the diagnosis of liver affection due to SARS-CoV-2 infection.

Indexed as

Autoimmune hemolytic anemiaIntracytoplasmic globulesPathologySARS-CoV-2

Identifiers

PMID34777872
PMCPMC8381346
OpenAlexW3193454283

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.