ArticleNeuro-oncology practice2021
Variations in the management of diffuse low-grade gliomas-A Scandinavian multicenter study.
Article in Neuro-oncology practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Asleep motor mapping in resected low-grade gliomas -a population based multicenter study.Brain & spine · 2026Article
- Patient selection and outcome in low-grade glioma surgery.Frontiers in oncology · 2025Article
- Unravelling differences and hallmarks in suspected diffuse low-grade gliomas: a multicentre database study.Brain communications · 2025Article
- Utility of Early Postoperative DWI to Assess the Extent of Resection of Adult-Type World Health Organization Grade 2 and 3 Diffuse Gliomas.AJNR. American journal of neuroradiology · 2024Observational
- Brain stimulation and elicited memories.Acta neurochirurgica · 2023Review
- The first case of glioma detected by an artificial intelligence algorithm running on real-time data in neurosurgery: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- The Concept of «Peritumoral Zone» in Diffuse Low-Grade Gliomas: Oncological and Functional Implications for a Connectome-Guided Therapeutic Attitude.Brain sciences · 2022Review
- Eloquent Lower Grade Gliomas, a Highly Vulnerable Cohort: Assessment of Patients' Functional Outcome After Surgery Based on the LoG-Glio Registry.Frontiers in oncology · 2022Article
- Classification of Adverse Events Following Surgery in Patients With Diffuse Lower-Grade Gliomas.Frontiers in oncology · 2021Article
- Is tumor shape associated with molecular diagnosis, extent of resection, or postoperative focal deficits in diffuse low-grade gliomas?Neuro-oncology advancesArticle
- Clinical application of machine-based deep learning in patients with radiologically presumed adult-type diffuse glioma grades 2 or 3.Neuro-oncology advancesArticle
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Authors and funding
27 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly extensive surgery is a cornerstone in treatment of diffuse low-grade gliomas (DLGGs), and an additional survival benefit has been demonstrated from early radiochemotherapy in selected "high-risk" patients. Still, there are a number of controversies related to DLGG management. The objective of this multicenter population-based cohort study was to explore potential variations in diagnostic work-up and treatment between treating centers in 2 Scandinavian countries with similar public health care systems.
methodsPatients screened for inclusion underwent primary surgery of a histopathologically verified diffuse WHO grade II glioma in the time period 2012 through 2017. Clinical and radiological data were collected from medical records and locally conducted research projects, whereupon differences between countries and inter-hospital variations were explored.
resultsA total of 642 patients were included (male:female ratio 1:4), and annual age-standardized incidence rates were 0.9 and 0.8 per 100 000 in Norway and Sweden, respectively. Considerable inter-hospital variations were observed in preoperative work-up, tumor diagnostics, surgical strategies, techniques for intraoperative guidance, as well as choice and timing of adjuvant therapy.
conclusionsDespite geographical population-based case selection, similar health care organizations, and existing guidelines, there were considerable variations in DLGG management. While some can be attributed to differences in clinical implementation of current scientific knowledge, some of the observed inter-hospital variations reflect controversies related to diagnostics and treatment. Quantification of these disparities renders possible identification of treatment patterns associated with better or worse outcomes and may thus represent a step toward more uniform evidence-based care.
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