Evidence map›Paper›PMID 34777769›Full record

ArticleChemical science2021

Modelling the active SARS-CoV-2 helicase complex as a basis for structure-based inhibitor design.

Dénes Berta, Magd Badaoui, Sam Alexander Martino, Pedro J Buigues, Andrei V Pisliakov, Nadia Elghobashi-Meinhardt, Geoff Wells, Sarah A Harris, Elisa Frezza, Edina Rosta

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Dénes BertaDepartment of Physics and Astronomy, University College London London WC1E 6BT UK e.rosta@ucl.ac.uk.ORCID https://orcid.org/0000-0002-8299-3784
Magd BadaouiDepartment of Physics and Astronomy, University College London London WC1E 6BT UK e.rosta@ucl.ac.uk.ORCID https://orcid.org/0000-0001-9521-6696
Sam Alexander MartinoDepartment of Physics and Astronomy, University College London London WC1E 6BT UK e.rosta@ucl.ac.uk.ORCID https://orcid.org/0000-0003-2813-1777
Pedro J BuiguesDepartment of Physics and Astronomy, University College London London WC1E 6BT UK e.rosta@ucl.ac.uk.ORCID https://orcid.org/0000-0003-1198-0609
Andrei V PisliakovComputational Biology, School of Science and Engineering, School of Life Sciences, University of Dundee Dow Street Dundee DD1 5EH UK a.pisliakov@dundee.ac.uk.ORCID https://orcid.org/0000-0003-1536-0589
Nadia Elghobashi-MeinhardtDepartment of Chemistry, Technische Universität Berlin 10623 Berlin Germany n.elghobashi-meinhardt@campus.tu-berlin.de.ORCID https://orcid.org/0000-0002-1023-6856
Geoff WellsUCL School of Pharmacy, University College London 29/39 Brunswick Square London WC1N 1AX UK g.wells@ucl.ac.uk.ORCID https://orcid.org/0000-0002-0253-911X
Sarah A HarrisSchool of Physics & Astronomy, University of Leeds Leeds LS2 9JT UK s.a.harris@leeds.ac.uk.ORCID https://orcid.org/0000-0002-2812-1651
Elisa FrezzaUniversité de Paris, CiTCoM, CNRS F-75006 Paris France elisa.frezza@parisdescartes.fr.ORCID https://orcid.org/0000-0003-0122-7859
Edina RostaDepartment of Physics and Astronomy, University College London London WC1E 6BT UK e.rosta@ucl.ac.uk.ORCID https://orcid.org/0000-0002-9823-4766
King's College London · GBCentre National de la Recherche Scientifique · FRTechnische Universität Berlin · DEUniversity College London · GBUniversity of Dundee · GBUniversity of Leeds · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The RNA helicase (non-structural protein 13, NSP13) of SARS-CoV-2 is essential for viral replication, and it is highly conserved among the

Identifiers

PMID34777769
PMCPMC8528070
OpenAlexW3196897520

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.