Evidence map›Paper›PMID 34777479›Full record

ReviewFrontiers in genetics2021

A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use-The P5 Study.

Heidi Marjonen, Minttu Marttila, Teemu Paajanen, Marleena Vornanen, Minna Brunfeldt, Anni Joensuu, Otto Halmesvaara, Kimmo Aro, Mervi Alanne-Kinnunen, Pekka Jousilahti and 10 more

Abstract readReview
In one paragraph

Review in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Heidi MarjonenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Minttu MarttilaDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Teemu PaajanenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Marleena VornanenDepartment of Social Research, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland.
Minna BrunfeldtDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Anni JoensuuDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Otto HalmesvaaraDepartment of Social Research, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland.
Kimmo AroNegen Ltd., Helsinki, Finland.
Mervi Alanne-KinnunenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Pekka JousilahtiDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Katja BorodulinDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Seppo KoskinenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Tiinamaija TuomiResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Pirjo Ilanne-ParikkaFinnish Diabetes Association, Tampere, Finland.
Jaana LindströmDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Merja K LaineFolkhälsan Research Centre, Helsinki, Finland.
Kirsi AuroDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Helena KääriäinenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Markus PerolaDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Kati KristianssonDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person's future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care.

Indexed as

coronary heart diseasefinhealth 2017 studyP5 studypolygenic risk soreprecision population healthtype 2 diabetesvenous thromboembolismweb portal

Identifiers

PMID34777479
PMCPMC8585790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.