Evidence map›Paper›PMID 34777391›Full record

ArticleFrontiers in immunology2021

Multifunctional, TNF-α and IFN-γ-Secreting CD4 and CD8 T Cells and CD8

Lorranny Santana Rodrigues, Aline Silva Barreto, Lays Gisele Santos Bomfim, Marcos Couto Gomes, Nathalia Luisa Carlos Ferreira, Geydson Silveira da Cruz, Lucas Sousa Magalhães, Amélia Ribeiro de Jesus, Clarisa B Palatnik-de-Sousa, Cristiane Bani Corrêa and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Cytotoxic CD4Parasite immunology · 2026
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  6. Review
  7. Frontiers in microbiology · 2026
    Article
  8. Article
  9. Article
  10. Protein dysregulation duringFrontiers in immunology · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. CD4Frontiers in immunology · 2024
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lorranny Santana RodriguesDepartment of Medicine, Federal University of Sergipe, Immunology Investigative Institute (III), National Insitute of Science and Technology (INCT), National Council for Scientific and Technological Development (CNPq), Aracaju, Brazil.
Aline Silva BarretoDepartment of Medicine, Federal University of Sergipe, Immunology Investigative Institute (III), National Insitute of Science and Technology (INCT), National Council for Scientific and Technological Development (CNPq), Aracaju, Brazil.
Lays Gisele Santos BomfimDepartment of Medicine, Federal University of Sergipe, Immunology Investigative Institute (III), National Insitute of Science and Technology (INCT), National Council for Scientific and Technological Development (CNPq), Aracaju, Brazil.
Marcos Couto GomesDepartment of Medicine, Federal University of Sergipe, Immunology Investigative Institute (III), National Insitute of Science and Technology (INCT), National Council for Scientific and Technological Development (CNPq), Aracaju, Brazil.
Nathalia Luisa Carlos FerreiraDepartment of Medicine, Federal University of Sergipe, Immunology Investigative Institute (III), National Insitute of Science and Technology (INCT), National Council for Scientific and Technological Development (CNPq), Aracaju, Brazil.
Geydson Silveira da CruzGraduate Program in Health Sciences, Federal University of Sergipe, Sergipe, Brazil.
Lucas Sousa MagalhãesDepartment of Medicine, Federal University of Sergipe, Immunology Investigative Institute (III), National Insitute of Science and Technology (INCT), National Council for Scientific and Technological Development (CNPq), Aracaju, Brazil.
Amélia Ribeiro de JesusDepartment of Medicine, Federal University of Sergipe, Immunology Investigative Institute (III), National Insitute of Science and Technology (INCT), National Council for Scientific and Technological Development (CNPq), Aracaju, Brazil.
Clarisa B Palatnik-de-SousaGraduate Program in Health Sciences, Federal University of Sergipe, Sergipe, Brazil.
Cristiane Bani CorrêaGraduate Program in Health Sciences, Federal University of Sergipe, Sergipe, Brazil.
Roque Pacheco de AlmeidaDepartment of Medicine, Federal University of Sergipe, Immunology Investigative Institute (III), National Insitute of Science and Technology (INCT), National Council for Scientific and Technological Development (CNPq), Aracaju, Brazil.
National Council for Scientific and Technological Development · BRUniversidade Federal de Sergipe · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visceral leishmaniasis (VL) is a chronic and often fatal disease caused by protozoans of the genus

Indexed as

AdultAntigens, ProtozoanBiomarkersCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesFemaleHost-Parasite InteractionsHumansInterferon-gammaLeishmaniasis, VisceralMaleMemory T CellsMiddle AgedT-Lymphocyte SubsetsTumor Necrosis Factor-alphaYoung AdultAntigens, ProtozoanBiomarkersInterferon-gammaTumor Necrosis Factor-alphacellular immunityhuman visceral leishmaniasisimmunophenotypingLeishmania (L.) infantum chagasimultifunctionalT-cell subsets

Identifiers

PMID34777391
PMCPMC8581227
OpenAlexW3210000746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.