Evidence map›Paper›PMID 34777335›Full record

ArticleFrontiers in immunology2021

Macrophage Selenoproteins Restrict Intracellular Replication of

Rachel L Markley, Katherine H Restori, Bhuvana Katkere, Sarah E Sumner, McKayla J Nicol, Anastasia Tyryshkina, Shaneice K Nettleford, David R Williamson, David E Place, Kalyan K Dewan and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Diverse roles of low-molecular weight thiol GSH inCurrent research in microbial sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Rachel L MarkleyPathobiology Graduate Program, The Pennsylvania State University, University Park, PA, United States.
Katherine H RestoriDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States.
Bhuvana KatkereDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States.
Sarah E SumnerPathobiology Graduate Program, The Pennsylvania State University, University Park, PA, United States.
McKayla J NicolPathobiology Graduate Program, The Pennsylvania State University, University Park, PA, United States.
Anastasia TyryshkinaNeuroscience Graduate Program, Huck Institute of the Life Sciences, The Pennsylvania State University, University Park, PA, United States.
Shaneice K NettlefordPathobiology Graduate Program, The Pennsylvania State University, University Park, PA, United States.
David R WilliamsonDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States.
David E PlaceDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States.
Kalyan K DewanDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States.
Ashley E ShayDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States.
Bradley A CarlsonOffice of Research Support, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Santhosh GirirajanDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, United States.
K Sandeep PrabhuDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States.
Girish S KirimanjeswaraDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States.
Pennsylvania State University · USBrigham and Women's Hospital · USNational Cancer Institute · USSt. Jude Children's Research Hospital · USUniversity of Georgia · US

Funding

NRSA Training CoreTL1TR002016 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI THOMAS, GAIL D. · 2016 to 2025
$3.4M
Research Training in Physiological Adaptations to StressT32GM108563 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T, KORZICK, DONNA HOPE · 2014 to 2023
$2.2M
Regulation of B cells by SeleniumR01AI123521 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI KIRIMANJESWARA, GIRISH S · 2016 to 2020
$2.0M
Penn State Biomedical Big Data to Knowledge (B2D2K) Training ProgramT32LM012415 · NLM · PENNSYLVANIA STATE UNIVERSITY, THE · PI BROACH, JAMES R., HONAVAR, VASANT G. · 2016 to 2020
$1.2M
Training in Animal Models of InflammationT32AI074551 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI GIBLIN, PAMELA A · 2011 to 2015
$940k
Mechanism of Antibody-mediated Immunity against F. tularensisR00AI077917 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI KIRIMANJESWARA, GIRISH S · 2011 to 2012
$490k
Cellular Basis for Genetic Susceptibility to Neurodevelopmental DisordersR21NS122398 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI GIRIRAJAN, SANTHOSH · 2021 to 2021
$428k
NCATS NIH HHS TL1 TR002016NIAID NIH HHS R00 AI077917NIAID NIH HHS R01 AI123521NIAID NIH HHS T32 AI074551NIGMS NIH HHS T32 GM108563NINDS NIH HHS R21 NS122398NLM NIH HHS T32 LM012415
6 · The paper itself

Abstract

The essential micronutrient Selenium (Se) is co-translationally incorporated as selenocysteine into proteins. Selenoproteins contain one or more selenocysteines and are vital for optimum immunity. Interestingly, many pathogenic bacteria utilize Se for various biological processes suggesting that Se may play a role in bacterial pathogenesis. A previous study had speculated that

Indexed as

AnimalsDisease Models, AnimalDisease SusceptibilityFrancisella tularensisHost-Pathogen InteractionsMacrophagesMicePneumoniaSelenoproteinsTularemiaVirulenceVirulence FactorsSelenoproteinsVirulence Factorsinnate immunityintracellular bacteriaredoxseleniumtularemia

Identifiers

PMID34777335
PMCPMC8586653
OpenAlexW3209889635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.