Evidence map›Paper›PMID 34777234›Full record

ArticleFrontiers in neurology2021

Brain Structural Alterations, Diabetes Biomarkers, and Cognitive Performance in Older Adults With Dysglycemia.

Dae Jong Oh, Ji-Jung Jung, Seong A Shin, Hairin Kim, Soowon Park, Bo Kyung Sohn, Bo Kyung Koo, Min Kyong Moon, Yu Kyeong Kim, Jun-Young Lee

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Effect of curcumin andFrontiers in neuroscience · 2026
    Article
  4. Article
  5. Brain [Brain communications · 2025
    Article
  6. Article
  7. Review
  8. Chemokine CX3CL1 (Fractalkine) Signaling and Diabetic Encephalopathy.International journal of molecular sciences · 2024
    Review
  9. Glial cell alterations in diabetes-induced neurodegeneration.Cellular and molecular life sciences : CMLS · 2024
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Dae Jong OhDepartment of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.
Ji-Jung JungDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea.
Seong A ShinDepartment of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, South Korea.
Hairin KimDepartment of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, South Korea.
Soowon ParkDivision of Teacher Education, College of General Education for Truth, Sincerity and Love, Kyonggi University, Suwon, South Korea.
Bo Kyung SohnDepartment of Psychiatry, Inje University Sanggye Paik Hospital, Seoul, South Korea.
Bo Kyung KooDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Min Kyong MoonDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Yu Kyeong KimDepartment of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, South Korea.
Jun-Young LeeDepartment of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, South Korea.
SNUH SMG-SNU Boramae Medical Center · KRSeoul National University · KRInje University Sanggye Paik Hospital · KRKyonggi University · KRSeoul National University Bundang Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the high risk of dementia in older adults with type 2 diabetes, the neuroanatomical correlates of cognitive dysfunction that are particularly affected by diabetes are not well characterized. This study is aimed to examine the structural brain alterations in dysglycemic older adults. Using voxel-based morphometric and tract-based spatial statistics, we examined changes in gray matter volume, white matter volume, and microstructural integrity in older adults with prediabetes and diabetes. We also assessed the correlation of these structural changes with diabetes biomarkers and cognitive performance. A total of 74 non-demented older adults (normal,

Indexed as

brain structurecognitiondiabetesdysglycemiaprediabeteswhite matter integrity

Identifiers

PMID34777234
PMCPMC8581483
OpenAlexW3210426145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.