Evidence map›Paper›PMID 34777227›Full record

SynthesisFrontiers in neurology2021

Sex Differences in Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.

Lorena Jiménez-Sánchez, Olivia K L Hamilton, Una Clancy, Ellen V Backhouse, Catriona R Stewart, Michael S Stringer, Fergus N Doubal, Joanna M Wardlaw

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The role of dopamine decline, astrocyte reactivity and cerebral small-vessel disease in cognitive aging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lorena Jiménez-SánchezTranslational Neuroscience PhD Programme, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Olivia K L HamiltonTranslational Neuroscience PhD Programme, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Una ClancyEdinburgh Dementia Research Centre in the UK Dementia Research Institute, Edinburgh, United Kingdom.
Ellen V BackhouseEdinburgh Dementia Research Centre in the UK Dementia Research Institute, Edinburgh, United Kingdom.
Catriona R StewartEdinburgh Dementia Research Centre in the UK Dementia Research Institute, Edinburgh, United Kingdom.
Michael S StringerEdinburgh Dementia Research Centre in the UK Dementia Research Institute, Edinburgh, United Kingdom.
Fergus N DoubalEdinburgh Dementia Research Centre in the UK Dementia Research Institute, Edinburgh, United Kingdom.
Joanna M WardlawEdinburgh Dementia Research Centre in the UK Dementia Research Institute, Edinburgh, United Kingdom.
University of Edinburgh · GBUK Dementia Research Institute · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)cerebral small vessel disease (SVD)lacunar strokesex differencesvascular dementia (VaD)

Identifiers

PMID34777227
PMCPMC8581736
OpenAlexW3210362538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.