Evidence map›Paper›PMID 34777225›Full record

ArticleFrontiers in neurology2021

S1 Brain Connectivity in Carpal Tunnel Syndrome Underlies Median Nerve and Functional Improvement Following Electro-Acupuncture.

Harrison Fisher, Roberta Sclocco, Yumi Maeda, Jieun Kim, Cristina Malatesta, Jessica Gerber, Joseph Audette, Norman Kettner, Vitaly Napadow

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Harrison FisherDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Roberta ScloccoDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Yumi MaedaDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Jieun KimDivision of Clinical Medicine, Korea Institute of Oriental Medicine, Daejeon, South Korea.
Cristina MalatestaDepartment of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, MA, United States.
Jessica GerberDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Joseph AudetteDepartment of Pain Medicine, Harvard Vanguard Medical Associates, Atrium Health, Boston, MA, United States.
Norman KettnerDepartment of Radiology, Logan University, Chesterfield, MO, United States.
Vitaly NapadowDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.
Athinoula A. Martinos Center for Biomedical Imaging · USSpaulding Rehabilitation Hospital · USHarvard University · USHarvard Vanguard Medical Associates · USKorea Institute of Oriental Medicine · KRLogan University · USMassachusetts General Hospital · US

Funding

ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BOAS, DAVID A · 1999 to 2011
$16.4M
Core NIBSP01AT009965 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI NAPADOW, VITALY, ROSEN, BRUCE R · 2018 to 2023
$10.9M
Brain Plasticity in Carpal Tunnel Syndrome and its Response to AcupunctureR01AT004714 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI NAPADOW, VITALY · 2008 to 2012
$4.5M
Neuroimaging Approaches to Deconstructing Acupuncuture for Chronic PainR01AT007550 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARRIS, RICHARD E, NAPADOW, VITALY · 2013 to 2019
$3.4M
Optimization of brain-based mechanisms supporting psychosocial aspects of acupuncture therapy - a hyperscanning fMRI studyR33AT009306 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KAPTCHUK, TED, NAPADOW, VITALY · 2018 to 2021
$2.3M
SILICON GRAPHICS PRISM EXTREME 128P/1TBS10RR023043 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$1.5M
Optimization of brain-based mechanisms supporting psychosocial aspects of acupuncture therapy - a hyperscanning fMRI studyR61AT009306 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KAPTCHUK, TED, NAPADOW, VITALY · 2016 to 2017
$959k
A Siemens MAGNETOTOM Trio 3 Tesla MRI SystemS10RR021110 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2006 to 2006
$500k
NCCIH NIH HHS P01 AT009965NCCIH NIH HHS R01 AT004714NCCIH NIH HHS R01 AT007550NCCIH NIH HHS R33 AT009306NCCIH NIH HHS R61 AT009306NCRR NIH HHS P41 RR014075NCRR NIH HHS S10 RR021110NCRR NIH HHS S10 RR023043
6 · The paper itself

Abstract

Carpal Tunnel Syndrome (CTS) is a median nerve entrapment neuropathy that alters primary somatosensory cortex (S1) organization. While electro-acupuncture (EA), a form of peripheral neuromodulation, has been shown to improve clinical and neurophysiological CTS outcomes, the role of EA-evoked brain response during therapy (within and beyond S1) for improved outcomes is unknown. We investigated S1-associated whole brain fMRI connectivity during both a resting and sustained EA stimulation state in age-matched healthy controls (

Indexed as

carpal tunnel syndromeelectro-acupuncturefunctional connectivityfunctional magnetic resonance imagingperipheral nerve function

Identifiers

PMID34777225
PMCPMC8578723
OpenAlexW3208648238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.