Evidence map›Paper›PMID 34777017›Full record

ArticleFrontiers in physiology2021

KairoSight: Open-Source Software for the Analysis of Cardiac Optical Data Collected From Multiple Species.

Blake L Cooper, Chris Gloschat, Luther M Swift, Tomas Prudencio, Damon McCullough, Rafael Jaimes, Nikki G Posnack

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Electroanatomical adaptations in the guinea pig heart from neonatal to adulthood.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  4. Evaluation of novel open-source software for cardiac optical mapping.Journal of molecular and cellular cardiology plus · 2024
    Article
  5. Article
  6. Evidence for the cardiodepressive effects of the plasticizer di-2-ethylhexyl phthalate.Toxicological sciences : an official journal of the Society of Toxicology · 2023
    Article
  7. Paralysis by analysis: Overcoming cardiac contraction with computer vision.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. The effect of sex and age on ex vivo cardiac electrophysiology: insight from a guinea pig model.American journal of physiology. Heart and circulatory physiology · 2023
    Article
  13. Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Blake L CooperSheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, United States.
Chris GloschatSheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, United States.
Luther M SwiftSheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, United States.
Tomas PrudencioSheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, United States.
Damon McCulloughSheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, United States.
Rafael JaimesSheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, United States.
Nikki G PosnackSheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC, United States.
Children's National · USGeorge Washington University · US

Funding

Does Biocompatibility Contribute to Transfusion-Related Adverse Effects?R01HL139472 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI Nikki Gillum Posnack · 2018 to 2026
$5.2M
NHLBI NIH HHS R01 HL139472
6 · The paper itself

Abstract

Cardiac optical mapping, also known as optocardiography, employs parameter-sensitive fluorescence dye(s) to image cardiac tissue and resolve the electrical and calcium oscillations that underly cardiac function. This technique is increasingly being used in conjunction with, or even as a replacement for, traditional electrocardiography. Over the last several decades, optical mapping has matured into a "gold standard" for cardiac research applications, yet the analysis of optical signals can be challenging. Despite the refinement of software tools and algorithms, significant programming expertise is often required to analyze large optical data sets, and data analysis can be laborious and time-consuming. To address this challenge, we developed an accessible, open-source software script that is untethered from any subscription-based programming language. The described software, written in python, is aptly named "

Indexed as

cardiac electrophysiologyexcitation contraction couplinghuman induced pluripotent stem cell derived cardiomyocytesLangendorff modeloptical mapping of calcium and action potentialsoptocardiographypythonspecies differences

Identifiers

PMID34777017
PMCPMC8586513
OpenAlexW3210581188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.