Evidence map›Paper›PMID 34777005›Full record

ArticleFrontiers in physiology2021

Asymmetric Interplay Between K

Tobias S Gabriel, Ulf-Peter Hansen, Martin Urban, Nils Drexler, Tobias Winterstein, Oliver Rauh, Gerhard Thiel, Stefan M Kast, Indra Schroeder

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Similarity of the ion occupations of KChannels (Austin, Tex.) · 2026
    Article
  2. Modular architecture of KEMBO reports · 2025
    Review
  3. Article
  4. Structural determinants of ivabradine block of the open pore of HCN4.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Tobias S GabrielPlant Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, Germany.
Ulf-Peter HansenDepartment of Structural Biology, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
Martin UrbanPhysikalische Chemie III, Technische Universita̋t Dortmund, Dortmund, Germany.
Nils DrexlerInstitute of Physiology II, University Hospital Jena, Friedrich Schiller University Jena, Jena, Germany.
Tobias WintersteinPlant Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, Germany.
Oliver RauhPlant Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, Germany.
Gerhard ThielPlant Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, Germany.
Stefan M KastPhysikalische Chemie III, Technische Universita̋t Dortmund, Dortmund, Germany.
Indra SchroederPlant Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, Germany.
Technical University of Darmstadt · DEFriedrich Schiller University Jena · DETU Dortmund University · DEKiel University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modulating the activity of ion channels by blockers yields information on both the mode of drug action and on the biophysics of ion transport. Here we investigate the interplay between ions in the selectivity filter (SF) of K

Indexed as

3D RISMblocker kineticscarbonyl-ion interactionextended beta distributionsion bindingselectivity filterviral potassium channels

Identifiers

PMID34777005
PMCPMC8586521
OpenAlexW3208848417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.