Evidence map›Paper›PMID 34776994›Full record

ReviewFrontiers in physiology2021

Periodontal Inflammation and Systemic Diseases: An Overview.

Mireya Martínez-García, Enrique Hernández-Lemus

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 304 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
304citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06984237 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Psoriasis and Periodontitis Are Chronic Inflammatory Diseases That May Share Common Immunopathogenic Pathways. TNF-α, IL-17A, and YKL-40 Are Inflammatory Biomarkers Associated With Both Conditions. This Study Aims to Evaluate the Levels of These Markers in Saliva and Serum of Individuals With Psoriasis, Considering Their Periodontal Status, to Investigate a Potential Link Between the Two Diseases

TypeobservationalSponsorAkdeniz UniversityRan2024 to 2025Enrolled100ConditionsPeriodontitis, PsoriasisArmsTNF-α Analysis in saliva, IL-17A analysis in saliva, YKL-40 Analysis in saliva, TNF-α analysis in serum, IL-17A analysis in serum
NCT07689786 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Using Miswak in Addition to Oral Hygiene Products in Patients With Gingivitis

Typeobservational_patient_registrySponsorMustafa Kemal UniversityRan2026 to 2027Enrolled36ConditionsGingivitis, ChronicArmsMiswak, Toothpaste
3 · Its place in the literature

Who cites it

304 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  5. Bladder cancer risk factors: a comprehensive umbrella review of meta-analyses.International journal of surgery (London, England) · 2026
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244 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mireya Martínez-GarcíaSociomedical Research Unit, National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico.
Enrique Hernández-LemusComputational Genomics Division, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis is a common inflammatory disease of infectious origins that often evolves into a chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis has gained relevance since it has been shown that it can develop into a systemic condition characterized by unresolved hyper-inflammation, disruption of the innate and adaptive immune system, dysbiosis of the oral, gut and other location's microbiota and other system-wide alterations that may cause, coexist or aggravate other health issues associated to elevated morbi-mortality. The relationships between the infectious, immune, inflammatory, and systemic features of periodontitis and its many related diseases are far from being fully understood and are indeed still debated. However, to date, a large body of evidence on the different biological, clinical, and policy-enabling sources of information, is available. The aim of the present work is to summarize many of these sources of information and contextualize them under a systemic inflammation framework that may set the basis to an integral vision, useful for basic, clinical, and therapeutic goals.

Indexed as

chronic inflammationcytokinesmolecular mechanismsoral pathogensperiodontitissystemic diseasessystemic inflammation

Identifiers

PMID34776994
PMCPMC8578868

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.