Evidence map›Paper›PMID 34776974›Full record

ArticleFrontiers in pharmacology2021

Chinese Patent Medicine Liuweiwuling Tablet had Potent Inhibitory Effects on Both Wild-Type and Entecavir-Resistant Hepatitis B Virus (HBV)

Fei-Lin Ge, Lan-Lan Si, Yan Yang, Yuan-Hua Li, Zhong-Lin Lv, Wen-Hui Liu, Hao Liao, Jun Wang, Jun Zou, Le Li and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Inhibition of hepatitis B virusWorld journal of gastroenterology · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Fei-Lin GeSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Lan-Lan SiDepartment of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Yan YangDepartment of Liver Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Yuan-Hua LiDepartment of Liver Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Zhong-Lin LvDepartment of Hematology, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Wen-Hui LiuDepartment of Gastroenterology, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Hao LiaoDepartment of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Jun WangDepartment of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Jun ZouDepartment of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Le LiDepartment of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Hui LiDepartment of Liver Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Zi-Lin ZhangDepartment of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Jia-Bo WangDepartment of Liver Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Xue-Chun LuDepartment of Hematology, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Dong-Ping XuDepartment of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Zhao-Fang BaiDepartment of Liver Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Yan LiuDepartment of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Xiao-He XiaoDepartment of Liver Diseases, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China.
Chinese PLA General Hospital · CNBeijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liuweiwuling Tablet (LWWL) is a licensed Chinese patent medicine (approval number: Z20060238) included in the national health insurance for anti-inflammation of chronic HBV infection, whereas its anti-HBV effect remains clarification. The study aimed to clarify its antiviral effect and related mechanisms. HepG2.2.15 cells (wild-type HBV-replicating cells) and HepG2. A64 cells (entecavir-resistant HBV-replicating cells) were used for

Indexed as

active compoundsantiviral activityChinese patent medicineentecavir resistancehepatitis B virus

Identifiers

PMID34776974
PMCPMC8578813
OpenAlexW3211049624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.