Evidence map›Paper›PMID 34776941›Full record

ReviewFrontiers in pharmacology2021

Adverse Effects Associated With Currently Commonly Used Antifungal Agents: A Network Meta-Analysis and Systematic Review.

Yan-Li Yang, Zi-Jian Xiang, Jing-Hua Yang, Wen-Jie Wang, Zhi-Chun Xu, Ruo-Lan Xiang

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07215273 (A Phase 2, Multicenter, Randomized, Double-blind Study of Safety and Efficacy of EL219), which is not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07215273 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

A Phase 2, Multicenter, Randomized, Double-blind Study of Safety and Efficacy of EL219 (Turletricin) Versus Liposomal Amphotericin B or Voriconazole for Early Antifungal Therapy of Invasive Mould Infections (TREAT-1)

TypeinterventionalSponsorElion Therapeutics, Inc.Ran2026 to 2026Enrolled60ConditionsInvasive Mould InfectionArmsEL219, Active Comparator- IV Antifungal (LAmB or voriconazole)
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Drug-Related Halitosis: A Narrative Review.International dental journal · 2026
    Review
  6. Article
  7. Comment on studies of fungal necrotizing otitis externa: constructive proposals to strengthen translational impact via target trial emulation, tissue-anchored diagnosis, and structured long-term safety monitoring.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  8. Fungal necrotizing otitis externa; challenges in diagnosis and therapy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Terbinafine Resistance inAntibiotics (Basel, Switzerland) · 2025
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yan-Li YangDepartment of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Zi-Jian XiangBeijing Zhiyun Data Technology Co., Ltd., Beijing, China.
Jing-Hua YangBeijing Zhiyun Data Technology Co., Ltd., Beijing, China.
Wen-Jie WangBeijing Zhiyun Data Technology Co., Ltd., Beijing, China.
Zhi-Chun XuBeijing Zhiyun Data Technology Co., Ltd., Beijing, China.
Ruo-Lan XiangDepartment of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Beijing, China.
Peking Union Medical College Hospital · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adverse eventsantineoplastic agentsechinocandinsinvasive fungal infectionsliposomal amphotericin Btriazole

Identifiers

PMID34776941
PMCPMC8585744
OpenAlexW3208067742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.