Evidence map›Paper›PMID 34776936›Full record

ArticleFrontiers in aging neuroscience2021

Effects of Sex, Age, and Apolipoprotein E Genotype on Brain Ceramides and Sphingosine-1-Phosphate in Alzheimer's Disease and Control Mice.

Sandra den Hoedt, Simone M Crivelli, Frank P J Leijten, Mario Losen, Jo A A Stevens, Marina Mané-Damas, Helga E de Vries, Jochen Walter, Mina Mirzaian, Eric J G Sijbrands and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
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  7. Review
  8. Article
  9. Sphingolipids in Cerebrospinal Fluid and Plasma Lipoproteins ofJournal of Alzheimer's disease reports · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Sandra den HoedtDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.
Simone M CrivelliDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands.
Frank P J LeijtenDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.
Mario LosenDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands.
Jo A A StevensDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands.
Marina Mané-DamasDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands.
Helga E de VriesDepartment of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, VU Medical Center, Amsterdam UMC, Amsterdam, Netherlands.
Jochen WalterDepartment of Neurology, University Hospital Bonn, Venusberg Campus, Bonn, Germany.
Mina MirzaianDepartment of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, Netherlands.
Eric J G SijbrandsDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.
Johannes M F G AertsLeiden Institute of Chemistry, Leiden University, Leiden, Netherlands.
Adrie J M VerhoevenDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.
Pilar Martinez-MartinezDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands.
Monique T MulderDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.
Erasmus MC · NLMaastricht University · NLAmsterdam University Medical Centers · NLLeiden University · NLUniversity Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apolipoprotein ε4 (

Indexed as

agingAlzheimer’s diseaseapolipoprotein E4ceramideS1Psex differences

Identifiers

PMID34776936
PMCPMC8579780
OpenAlexW3209744566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.