Evidence map›Paper›PMID 34776863›Full record

ArticleFrontiers in molecular neuroscience2021

Extracellular Vesicles in Serum and Central Nervous System Tissues Contain microRNA Signatures in Sporadic Amyotrophic Lateral Sclerosis.

Ting-Wen Lo, Claudia Figueroa-Romero, Junguk Hur, Crystal Pacut, Evan Stoll, Calvin Spring, Rose Lewis, Athul Nair, Stephen A Goutman, Stacey A Sakowski and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 4 pooled it
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. miRNAs in neurodegenerative diseases: from target screening to precision therapy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  14. Circulating GLASTFrontiers in molecular biosciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ting-Wen LoDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, United States.
Claudia Figueroa-RomeroDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.
Junguk HurDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, United States.
Crystal PacutDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.
Evan StollDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, United States.
Calvin SpringDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, United States.
Rose LewisDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.
Athul NairDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.
Stephen A GoutmanDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.
Stacey A SakowskiDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.
Sunitha NagrathDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, United States.
Eva L FeldmanDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States.
University of Michigan–Ann Arbor · USUniversity of North Dakota · US

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
NCATS NIH HHS UL1 TR000433
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a terminalneurodegenerative disease. Clinical and molecular observations suggest that ALS pathology originates at a single site and spreads in an organized and prion-like manner, possibly driven by extracellular vesicles. Extracellular vesicles (EVs) transfer cargo molecules associated with ALS pathogenesis, such as misfolded and aggregated proteins and dysregulated microRNAs (miRNAs). However, it is poorly understood whether altered levels of circulating extracellular vesicles or their cargo components reflect pathological signatures of the disease. In this study, we used immuno-affinity-based microfluidic technology, electron microscopy, and NanoString miRNA profiling to isolate and characterize extracellular vesicles and their miRNA cargo from frontal cortex, spinal cord, and serum of sporadic ALS (

Indexed as

amyotrophic lateral sclerosisbiomarkercentral nervous systemextracellular vesiclemicroRNAneurodegenerationpathway analysisserum

Identifiers

PMID34776863
PMCPMC8586523
OpenAlexW3208499272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.