Evidence map›Paper›PMID 34776833›Full record

ArticleFood & nutrition research2021

Concentrated extract of Prunus mume fruit exerts dual effects in 3T3-L1 adipocytes by inhibiting adipogenesis and inducing beiging/browning.

Su Bu, Chunying Yuan, Fuliang Cao, Qifeng Xu, Yichun Zhang, Ronghua Ju, Longyun Chen, Zhong Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food & nutrition research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Foods (Basel, Switzerland) · 2024
    Article
  4. Review
  5. Review
  6. Effects of polysaccharides-richedCurrent research in food science · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Su BuCollege of Biology and the Environment, Nanjing Forestry University, Nanjing, China.
Chunying YuanCollege of Biology and the Environment, Nanjing Forestry University, Nanjing, China.
Fuliang CaoCo-innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.
Qifeng XuCollege of Biology and the Environment, Nanjing Forestry University, Nanjing, China.
Yichun ZhangCollege of Forestry, Nanjing Forestry University, Nanjing, China.
Ronghua JuNational Engineering Research Center of Biomaterials, Nanjing Forestry University, Nanjing, China.
Longyun ChenNanjing Longlijia Agricultural Development Co. Ltd., Nanjing, China.
Zhong LiNational Engineering Research Center of Biomaterials, Nanjing Forestry University, Nanjing, China.
Nanjing Forestry University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe fruit

objectiveWe assessed the effect of a concentrated water extract of

methodsThe cell viability was determined by MTT assay. Lipid accumulation was assessed with Oil Red O (ORO) staining under different concentrations of CEPM. The effects of CEPM treatment during differentiation on beiging/browning and mitochondrial biogenesis in 3T3-L1 cells were investigated.

resultsCEPM treatment suppressed differentiation and decreased lipid accumulation by downregulating the expression of key adipogenic genes, including PPARγ, C/EBPα, SREBP-1c, FAS, and perilipin A. In contrast, CEPM treatment increased the mitochondrial DNA (mtDNA) content and mRNA levels of mitochondrial biogenesis genes, including

conclusionThe first evidence we provided showed that CEPM has a dual role in 3T3-L1 cells inhibiting adipogenesis and promoting beiging/browning, and hence, could be a potential agent in the fight against obesity.

Indexed as

3T3-L1 adipocytesbeigingbrowningconcentrated water extract of Prunus mume fruit (CEPM)mitochondrial biogenesis

Identifiers

PMID34776833
PMCPMC8559450
OpenAlexW3209356537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.